SGLT2 inhibitors as Calorie Restriction mimetics

#1

SGLT2i are often compared in mode of action to calorie restriction mimetics. Here is a terrific paper that overviews the subject in the context of other CR mimetics, and pathways, such as utilized by rapamycin:

SGLT2 Inhibitors as Calorie Restriction Mimetics: Insights on Longevity Pathways and Age-Related Diseases

https://academic.oup.com/endo/article/162/8/bqab079/6226811?login=false

Quote:

“There has been longstanding interest in anti-aging pathway modulators that replace the benefits of CR. We present an overview of metformin, rapamycin, resveratrol and NAD+ boosters as alternative anti-aging compounds”.

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#2

Thanks. I wonder how many of the “mTOR inhibitors” are really just CR memetics rather than acting on mTOR directly as does rapamycin…

From this paper:
“ Downregulation of insulin/IGF1 pathways and mTOR signaling from a reduction in glucose and circulating amino acids promote cellular repair mechanisms, including autophagy and proteostasis which confer cellular stress resistance and attenuate cellular senescence.”

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