Steve thanks for all your input on this forum. I very much value your contributions, as well as those of many others here. My wife is 50kg and I’m 100kg body weight, and we are wanting to add yearly or twice yearly FOX04-DRI 6 day cycles to our protocols. We are in our mid-fifites. Ideally we would tailor the dosing to use up a given number of 10mg vials each time. Do both you and your wife take the same dose? And what are your body weights? If dosing is mg/kg dependent, it seems like I would take a double dose vs my wife’s dose, which would put me at 3.33mg daily x 6 days and my wife at 1.67mg daily x 6 days, which would use up (3) 10mg vials. Or with a slightly higher dose we could go with 4.44mg for me and 2.22mg for my wife to use up (4) 10mg vials. I’m leaning towards the latter option. Or perhaps to keep dosing a little simpler, we could take an introductory dose of 2.5mg for me and 1.5mg for her on day 1, then 4mg for me and 2mg for her for 6 additional days. Thanks in advance!
Good to know. I’ve recently begun to address secondary hypogonadism by starting a regimen of enclomiphene 12.5mg daily, hcg 250iu 3x/wk, and kisspeptin 100mcg 3x/wk. I plan to alternate short 4 week cycles of 3x/wk 100mcg kisspeptin 10 with 2 week cycles of 3x/wk 100mcg gonadorelin to decrease desensitization risk on each of these pathways. I will considering increasing any or all of these depending on lab results after 3 months.
You’re all over the place here, as hcg shuts down LH, while enclomiphene stimulates it. Drop one of them.
Kisspeptin will cause an acute spike in LH and FSH, but will not impact testosterone levels. For levels to rise, you would need an infusion. There is some risk of densentization with gonadorelin, just be aware of that at your dose. It also does nothing for testosterone levels.
There is only one compound in your stack that has been proven to treat secondary hypogonadism, I would stick with it. Consider the rest as add-ons/placebo; any positive results you can probably be explained by the work of that one compound.
I was directed by an HRT clinic to take enclomiphene and hcg at those doses. The kisspeptin/gonadorelin is my own doing.
I’m definitely considering bagging the whole thing and just taking exogenous Testosterone.
I guess they’re hedging their bets here, in case you’re an enclomiphene non-responder. Labs in 4 to 6 weeks should help here. If they show elevated LH and FSH, there’s a good chance you don’t need the hcg.
Maybe I’ll stop kisspeptin and skip gonadorelin for now. Maybe too many ingredients all at once. Thanks for your input. I was starting to think that too.
Sorry getting a little off topic of senolytics here. Thanks again.
Kisspeptin is relatively unstable in aqueous solution. I stopped using it as I was already using Gonadorelin, which is stable and did significantly increase my testosterone.
I’ve posted my most recent results with Gonadorelin up this thread somewhere.
Kisspeptin 10, to be effective, should be used the same day it’s reconstituted. Maybe 2 day but I would not count on more than 1 day.
Below is why I stopped using it.
kisspeptin 10 - stability in sterile water or PBS,.pdf (577.6 KB)
Thanks Steve! As far as Fox04-DRI dosing goes - If I’m double the size of my wife should I be getting a double dose of Fox04-DRI? I’m thinking 4.4mg for me (100 kilos) and 2.2mg for my wife (50 kilos) x 6 days.
Just started trying this : Tadalafil 2.5mg with Selegiline 1.25mg
Anyone else is doing similar?
When paired, When paired, these two compounds attack neurodegeneration via a structural “Two-Hit” model:
- Supply and Demand Matching: Tadalafil optimizes the macro-environment by ensuring consistent delivery of oxygen and glucose via enhanced blood flow. Selegiline optimizes the micro-environment inside the cell, making sure individual neurons are structurally resilient enough to utilize those nutrients efficiently and survive oxidative stress.
- Dual Neurotrophic Support: Both drugs independently support neurotrophic factors (BDNF from Tadalafil; NGF and GDNF from Selegiline), compounding the signal for synaptic repair and structural maintenance.
On the subject of senolytics, my wife and I are just finishing up a couple of days of D and Q. We are using a high absorption Quercetin along with Dasatinib. We are taking these after a decent breakfast and experiencing minor side effects. We are still able to have fairly normal activity on these couple of days with Bike rides and possibly some running or skiing.
Unless its an AQI of 1006 pm 2.5. Then its not the senolytics that keep us indoors. Kinda sucks not to be able to breath the air outside. Breathing seems pretty fundamental to our physiology. How does that fit with longevity? Maybe someone should start a thread about that one?
Have you ever seen those post apocalyptic movies where people wear air filters that look like WW1 gas masks outdoors? That’s the way we’re headed.
GHK-Cu is the only compound I know of to ameliorate lung damage (in animal studies).
I’ve been mixing 2.5mg GHK-Cu + 0.5 KPV + 0.5 MT-1 injections for the last month, but I’ve use GHK-Cu for over a year now.
Don’t use MT-1 if you are using Quercetin as a senolytic before it will increase BCL protein in your cells, which is what D&Q combination is looking for.