While much of this article is a rehash of what is already known, there are some interesting tidbits scattered through out.
One aspect is about “markers” and it leads to a great group of researchers.
Better markers
Indeed, the issue of specificity is shared by all senolytic approaches, simply because there is more than one type of senescent cell. Researchers are only just beginning to uncover how many there are — and what markers they bear. “Without having really great biomarkers of senescent cells, it’s a little bit tricky to engage the right targets,” says Orr.
Orr is part of a large collaborative effort called the Cellular Senescence Network (SenNet), involving more than 200 researchers, that aims to produce atlases of senescent cells across the lifespan of humans and mice. Her team is using machine learning to improve definitions of brain-cell markers of senescence, then using them to map how senescent cells change with age and during dementia.
Ultimately, better markers of senescent cells will bring better senolytics that could one day prevent or treat age-related disease, she says. Ghosh echoes this optimism when it comes to killing zombie cells. “I think the fundamental science is so compelling that targeting senescent cells is definitely going to be of benefit.”