Oh my god, with so many similar statements, I never engage in endless questioning. I never question anyone for covering up risks by assuming they’re doing it for profit — I believe it’s just a common trait of biohackers, an aversion to risk. But when I’m subjected to malicious speculation, I’m truly speechless. Continuing the discussion would only make me look petty.
I for the life of me couldn’t come up with some financial interest you might have - I didn’t mean to imply that. I was just saying that I didn’t have any, bit it makes sense that you went there. And partly I get on that mind set because someone posted that docs are all against biohacking because it takes away our power and hurts our finances.
I was more thinking you had some experience with a negative outcome. I have a friend who knew 2 people who had pancreatitis while on GLP1s. That friend also happened to have some familial pancreatic cancer and was in a study with annual MRCP and EUS. So she has significant reservations. Well sure. Not necessarily correct but I can see the issue.
And if you are just a strict guideline person, ok. But this is a Rapamycin forum so maybe you aren’t going to find a lot of support here for that. And you might be subject to the argument that doctors have financial motivations to not support biohacking. I don’t agree with that argument personally but I can see where it comes from.
And while no one doctor’s finances are effected by some random person’s post on a forum, I am a huge believer in Upton Sinclair’s " lt is difficult to get a man to understand something when his salary depends on him upon his not understanding it." It is so easy for any of us (humans) to be groupthinked by our profession - and doctors are certainly not immune. Now, I’ve probably either alienated or insulted you but not my intent.
I do totally agree with your quotes post.
2 Likes
You have exposed a huge chip on your shoulder of misinformation.
And reminded me why I don’t visit this forum much anymore.
2 Likes
My theory is reward dampening leading to less use of food/drugs to soothe emotional pain leading to having to confront those issues directly. It might end up being a very useful psychological therapeutic tool if this is the mechanism.
“Concerns that GLP-1RAs raise the risk for acute pancreatitis and pancreatic cancer have been dispelled by long-term clinical trials. However, GLP-1RAs may confer an increased risk for thyroid cancer. Sight-threatening eye complications resulting from rapid reductions in glycemia may be avoided by retinal screening and ophthalmologic treatment before GLP-1RA initiation. The slowing of gastric emptying with GLP-1RA treatment increases the propensity for retained gastric contents, which could increase the risk of aspiration during upper gastrointestinal endoscopy or general anesthesia. These risks may, however, be elevated in individuals with long-standing T2D even in the absence of GLP-1RA treatment.”
Things almost all of us were aware of. Most side effects are GI in nature, or decreased muscle mass due to improper diet/lifestyle.
2 Likes
You’re saying people eat for reward?
Excuse me while I go grab a cookie for the dopamine hit it gives me.
People eat for a variety of reasons. Unfortunately hunger is not the only one. Boredom, stress, reward. GLP1s appear to hit hunger and reward. And strangely to me at least, that works for the boredom and stress eaters also although I am sure that weight loss is not as good in those cases.
Heck, even hunger exists on multiple levels. It is not just one thing though some authors seem to treat it like that.
4 Likes
I don’t know. I’ve been feeling subtly but noticeably more “down” since getting on tirza. I feel like on a dampened filter for everything. My HRV gets low too so I wonder if that’s causative. It’s a small shift but I pay close attention to my internal state and definitely not nocebo as I am bullshit on the drug. I’m not getting off any antidepressants or other mood altering drugs as I’ve never been on any.
I have been injecting equine joints with liraglutide a year non responsive horses are responding.
5 Likes
Yes. Living to eat vs. eating to live.
More details? Done under any kind of protocol? Anyone in the field doing under controlled conditions ?
How do you measure response and do you weigh the horses? I suspect you would get some systemic drug.
2 Likes
My protocol is 6mg for knees and coffins 10 mg for stifles. It lasts a lot longer than subq All horses have responded. The LASARE trial is going on in people. I am getting ready to inject with semiglutide and tirzepatide. There are GIP receptors in chondrocytes and synoviocytes that look like they will stimulate osteoblasts and clasts, great for OCD…If interested will do MOA, Have looked at joint fluid, I dont believe much is absorbed systemically and have had NO side effects.
3 Likes
Injecting with Liraglutide over a year. My protocol is 6mg for knees and coffins 10 mg for stifles. It lasts a lot longer than subq. All horses have responded. All horses no response or little response to modalities used for joints. The LASARE trial is going on in people. I am getting ready to inject with semiglutide and tirzepatide. There are GIP receptors in chondrocytes and synoviocytes that look like they will stimulate osteoblasts and clasts, great for OCD…If interested will do possible MOA, Have looked at joint fluid, I dont believe much is absorbed systemically and have had NO side effects. 30 horses so far. Although GLP is the bibby, GIP
I believeit is especially important in helping replace cartilage.
2 Likes
And yet before I ever started losing meaningful weight on tirzepatide, sense of well-being and just “feeling better” was almost immediate. I wonder if these drugs aren’t also potentially quite useful in menopause (with or without BHRT) for the metabolic problems that ensue but also the improvements in temperature regulation and all the other organ systems that show improvement. I can tolerate much warmer environments again and its a relief.
The joint damage repair potential is exciting. I notice after a shot for a few days a slight ache or sensitivity across many joints. Commonly reported by users in Reddit groups too. I have to wonder if the activation of the receptors in chondrocytes in this manner aren’t something we might also be feeling, literally, in some way.
I’d argue that might just be calorie restriction - which helps nearly everything.
But interesting about the joints noticing the shot. Could be lots of things but maybe…
1 Like
Kinda goes against the whole effectiveness of glp1’s
1 Like