Interestingly on this I took another high dose of Rapamycin on Sunday and did a blood test yesterday. The result for HbA1c today is 4.71%. (28 mmol/mol)
Adding to this. I monitor my resting heart rate from fitbit. This is higher when drinking than not drinking. However, in the week after taking a high dose of rapamycin it is perhaps 6-7 beats per minute higher post rapamycin than pre rapamycin (when not drinking). I think this is because serum glucose is higher.
I post this now as it is the same for the third dose. (ie higher)
I am not going to post another topic for the third high dose, but I would confirm from the early results that LDL-C goes up quite quickly although on this occasion Lp(a) has remained low and ApoB is 80. I am using a lab completely new to me, however.
@John_Hemming - this is awesome data- thanks so much for posting it in detail - and look forward to the next edition.
I have been measuring fasted glucose just using a finger prick and likewise - found a fasted blood glucose peak at 6.7 mm/ Dl, which at higher end of pre diabetic range is concerning.
I took 14mg (on a 2 weekly schedule) 3 days ago - and wake up fasted glucose has not peaked yet.
I have also found RHR and HRV materially worsens for 2-3 days after dose, which was the motivation to stretch out to 2 weekly - which I then found improved my averages overall rather than worsening.
I was going to post separately - but I am really interested in what other people do regarding elevated blood glucose from dosing?
Clearly having elevated glucose is not ideal and I guess that is, perhaps, why Rapa paried with Arcabose does so well on longevity as it counters this downside.
@RapAdmin - I know you have experimented with different glucose lowering meds + CGM to counter this. Where did you land with respect to the optimized protocol.
I will wear a CGM for the whole 2 weekly cycle next time to get data as well.
Super interested to know who has really measured their blood glucose over the dosing cycle and where you have landed with optimal dosing cycle and additional glucose lowering meds to optimise for this.
Thanks again.
I implanted a CGM yesterday to monitor what i expect to be a drop in average glucose. I am not fasting, but the overnight glucose has been pushed up again. I take berberine for various reasons i dont take anything other than ethanol to lower glucose.
I will post the charts again, but it wont be as well monitored. I have done this three times now. My last HbA1c was 4.71% so i am comfortable that pushing up fasting glucose is not creating dangerous peaks.
I am now also to monitor hair follicles and i think there is an objectively viewable improvement, but i need a particular mix of sun and artificial light to be sure.
Itβs interesting to me that despite my dose being 1/5th your effective dose, my casual observation of your blood glucose rises look similar to what I have observed.
So perhaps the glucose effect is binary and not particularly dose dependent
I think the glucose effect has a threshold. With a higher dose it lasts longer. If more people posted CGM charts we could work out any pattern. All things being equal 56mg would be 5 days at higher than 14mg 77mg may be about an extra day