Scientists Slow Aging With Artificial Antioxidant SkQ1

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Interesting - thanks for posting…

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May work better than MitoQ.

The advantage of SkQ1 is that the difference in concentrations between pro- and antioxidant activity is about 1000 fold. Experiments on mitochondria have shown that SkQ1 begins to exhibit antioxidant properties already at concentrations of 1 nM, and pro-oxidant properties at concentrations of about 1 μM. For comparison, this “concentration window” of MitoQ is only about 2-5 fold. The manifestation of antioxidant activity of MitoQ begins only with concentrations of 0.3 μM while it begins to demonstrate pro-oxidant effect at 0.6-1.0 μM.

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Just remember that the Russians have a high percentage of fake research papers along with the Chinese. Not sure how much this can be trusted without supporting evidence.

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FWIW

This is not a new compound{SkQ]

Produced and sold out of Russian for many years, medical approved{by the EU’s agency] as eye drops in Europe. The product is called Visomitin which uses SkQ1.{Their are several version of SkQ.

I used the product SkQ1 many times{since 2017], now a little more difficult to purchase due to the current geopolitical conflict.

I would provide a video documentary{produced by RT] about SkQ but RapAdmin will not allow{I was told by him, as one of my posting was removed because it was posted from/on RT ] NOT to post anything from Russian Today / RT{My comment, it should not matter from where science is from. A persons personal view/bias should not be based on a Country’s political issue.

Look up video titled;

“Skulachev project Jan 2013”
on YouTube.
Yes, this was produced in 2013 by RT

Skulachev has/was working on an IV version{of SkQ] among other deliver methods. The molecule{SkQ] is a carrier for other compounds to deliver a molecule into mitochondria and deposit/release the carried compound inside mitochondria.

You can imagine what you can do with this{SkQ].

SkQ was created in 1972 at Moscow State University.

If I recall correctly Günter Blobel Nobel prize{1999] was based on Skulachev’s work.

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Bit of Russophobia creeping in here.

The paper was co-written by Swedes AND peer reviewed and published in an American journal…

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In addition, Aging (Journal) lists its editorial board https://www.aging-us.com/editorial-board starting with

It is pretty easy to check up on the status or “rank” of a journal via https://www.scimagojr.com/journalrank.php?category=1302

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This is legitimate research, @RapAdmin. Does Rich Miller have any interest in this compound, or has the flop of MitoQ rendered all comparable substances uninteresting to him? Does anyone have the courage to shoot him an email?

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FWIW

I have been using the eye drops on and off since 2017.

Contact Information:

E-mail: millerr@umich.edu

Office Phone: 734 936 2122

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In that situation, I’d suggest letting the team at ITP take a look. I have confidence in their assessment.

I used the drops as well till last year when my supply ended. Will get new batch when a friend comes back from Moscow.

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SkQ1 treatment attenuated the manifestation of kyphosis and alopecia in mtDNA mutator mice
Already at an age of less than 230-250 days, mtDNA mutator mice show features normally associated with aging, as exemplified with the ≈250 days old mtDNA mutator mouse in Fig. 1A which confirms observations originally published by [12,13]. Strikingly, treatment of these mice with the SkQ1, not from birth but only from an age of ≈100 days, markedly diminished this phenotype, resulting in mice presenting a mouse much more similar to wild-type mice of this age (Fig. 1A). These dramatic improvements were quantitatively analyzed in the ensuing graphs.

Non-treated mtDNA mutator mice showed severe alopecia (hair loss) [12,13]. This pathology was much less evident in mice treated with SkQ1 (Fig. 1F). It may especially be noted that these cohorts of mice were single-caged. Thus, the alopecia and the loss of whiskers were mouse-autonomous effects. Earlier studies have kept mice in larger groups where mouse-mouse interaction (particularly between males) may substantially affect the outcome, leading to exaggerated fur loss (barbering). – As fur protects against heat loss [26] and as the mice were living at 22 °C, i.e. below their thermoneutral zone, the implication is that the SkQ1-induced amelioration of the fur status is not only a general indication of less rapid advancement of aging features but also that it can diminish the heat loss and thus the risk for hypothermia [27].

The same company also manufactures a skin cream. MitoVitan (Skulachev Ions, SkQ1 Anti-Aging serum)

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I’m interested in giving it a try. Is it currently possible to obtain it outside of Russia?

Look online, you should be able to locate.
Which item?

Do you think this is legitimate? SKQ1 Bromide – Solution (10mL / 30mL)

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Do you have a trusted seller you could please point me to? Thank you :blush: