“Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell’s lysosomes. The breakthrough, published in Cell Stem Cell , identifies lysosomal hyperactivation and dysfunction as key drivers of stem cell aging and shows that restoring lysosomal slow degradation can revitalize aged stem cells and enhance their regenerative capacity.”
Therapies to restore low lysosomal activity and the functional decline of old [hematopoietic stem cells (HSCs)]) are an active area of research, including gene therapy, metabolic senescence>> modulators like nicotinamide riboside (NR), and dietary interventions like prolonged fasting. Specific treatments and medications being explored or used for conditions like [lysosomal storage diseases (LSDs)] or aging include enzyme replacement therapy (ERT), substrate reduction therapy (SRT), and the use of compounds like N-acetylcysteine (NAC).
If only we had access to the more advanced therapies.