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Very interesting as it strengthens the emerging view that brain waste clearance is an important component of healthy brain ageing. It also gives researchers a potential way to test interventions rather than simply assuming they improve glymphatic function.
I noticed that these researchers are now establishing normal flow patterns in mice and hope eventually to compare:
- young vs. older brains
- healthy vs. Alzheimer’s brains
- normal vs. concussed brains (I have friends who have suffered serious concussions in sport).
It could eventually allow studies asking whether things such as; deep/slow-wave sleep, exercise, blood-pressure control, metabolic health or particular longevity interventions actually improve brain clearance.
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