Sorry I don’t have a time stamp. It was a month ago. I’m not motivated to listen to it again but I am not a religious diet person and don’t care what diet you follow: I expect that if I took the time to write it then that is what I heard from the presentation.
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An older paper to review;
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The Columbia research didn’t do any human supplementation: they are imputing the 6 g dose from allometric scaling. The only human data they gathered was observational, plus one study where they showed that a bout of endurance exercise elevated plasma T.
In the Yadav study, even 1000 mg/kg by gavage (which is the basis of the 6 g extrapolation) wasn’t enough to fully restore youthful T, so you would expect it would be better to go higher.
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Well, you’re missing having youthful taurine for over half the time. The Yadav study found taking half the dose once daily was less effective than taking the full dose; taking the full dose once every 48 hours seems less likely to allow your cells to operate youthfully.
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Attia isn’t saying there’s a downside: he’s saying he doesn’t think the mouse study can be extrapolated to humans. I disagree as noted in another post.
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Hmmmm… maybe you are right.
Guess I can do taurine in my 2nd coffee at work… and alternate Glycine/Collagen with AAKG in my wake up coffee at home. Always ready to adapt to new information. I suspect that my heavy steak diet helps in taurine too.
Just saw this in the news.
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Actually that’s what I’m doing now. Collagen and Glycine in my wake up coffee and then 8 g of taurine 3-5 hours later in my second round of coffee. Then some added glycine before bed.
That’s about 20g of glycine. I wonder if that’s too much?
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That’s also similar to what I am doing and the path I am likely to be on: 6g of glycine and15g collagen in two cups of coffee in the morning (with two teaspoons of unsweetened cocoa for LDL) with other supplements including 100mg NACET (which is supposedly equivalent to 1-2g of NACbut I probably should double this), 1000mg citrus bergamot (to try to lower LDL), 12mg astraxanthin, and 5,000 IU of vitamin D every other day (although Huberman is making me think I might be better off waiting 90 minutes after I wake to drink the coffee). I generally eat only between 5-9pm and eat a lot of protein (last night was salmon and chicken) so probably loads of amino acids (albeit not for signaling?). I have 2kg of creatine waiting to be used (accidental double order; don’t ask) and 1kg of beta-alanine (for carnosine), and waiting on taurine — I’m not sure how to work these into my schedule: creatine and beta-alanine in the middle of the day and taurine at night? Mixed in straight water? Weak tea (caffeine after noon makes me sleepless)?
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According to a livestock industry trade publication, “A 3-oz. beef steak would provide 55 mg taurine”
https://www.beefmagazine.com/policy/beef-has-a-great-story-on-the-amino-acid-taurine
The richest dietary sources are seafood, but even eating haddock all day long you’re not going to get 6 g of T.
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I appreciate your point and you are of course correct, but just as an aside, no carnivore is going to eat a 3oz steak: they’re eating 18oz steaks. That’s at least what I’m doing, and I’m a “delicate” carnivore eater. (Your point at 6x still stands correct)
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You simply can’t get enough taurine through a normal diet. You get some, but not enough to provide an optimal benefit like you could when you were young.
Therein lies the problem. Why does our body utilize so much less as we age?
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The “massive” lifespan extension in mice was in a flawed study with very short-liven controls. The GlyNac treated mice lived as long as regular mice, but for some reason the controls died very young. This doesn’t mean that GlyNac isn’t effective, just that this study doesn’t persuasively show it.
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The ITP did show that Glycine by itself dis increase lifespan in a statistically significant way but by a small extent. I hope they trial GLYNAC so that we can have a more definite answer.
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Had been taking 3g of taurine once per day for the last few months, with no noticable side effects (noticed nothing at all actually). Am increasing it to 6g per day now, because why not? It’s cheap and doesn’t seem to be much downside. Will do 3g in morning and 3g at night.
Two things that I have subjectively noticed: one or two grams taken with coffee in the morning mellows the effect of coffee. I can drink a lot of coffee and not get that wired feeling.
Also, taken in the evening after dinner seems to reduce the time it takes to fall asleep.
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I take all 6 g taurine with coffee in the late morning. I take 11 g of collagen and 6 g of glycine with my 6 am coffee. So far, I am liking the results. I still get my coffee energy but @desertshores you are right it feels less ‘wired’ and more ‘energized’.
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in the GLYNAC study they used C57BL 6 mice strain and in ITP they use, as far as I have read “genetically heterogeneous male and female mice”.
“The median lifespan of C57BL/6 mice range from 27 – 29 months, with the maximum being around 36 months.”
I have not found references to what lifespan one can expext from the mice in the ITP. Can someone elaborate on the expected lifespan of the mice used in the ITP.
Dr. Miller at the ITP has a very poor opinion about Black 6 mice. They are not genetically diverse enough to give good results. This is why the ITP doesn’t use them.
I found this regarding mice used in the ITP.
"As part of a 3-institution project funded by the National Institute of Aging, we are testing simple chemical interventions administered through food to determine if they retard aging and increase life span in mice. We consider an intervention successful if it increases insulin sensitivity and reduces chronic inflammation and susceptibility to oxidative damage, all of which are well-known indicators of retarded aging. We will test the most successful interventions in combinations at all centers.
Mice in the study are the 4-strain cross UM-HET3 (HET3) mice, the first generation offspring of CByB6F1/J and C3D2F1/J parents, first used by Miller et al. (1999) to study life spans. Thus, the tested populations are reproducible and represent great genetic diversity, helping to assure that results are not due to the responsiveness of a single genotype but more broadly represent laboratory mice in general. We are including a group of diet restricted HET-3 mice as positive controls because diet restriction is the “gold standard” for treatments that retard aging and increase life span."
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Yes, they use the HET-3 mice at the ITP.