A longevity-linked metabolite restored key memory processes in Alzheimer’s models, highlighting aging biology as a promising therapeutic target.
“Singapore ranks among the countries with the longest life expectancy, yet many people spend nearly ten of their later years living with poor health. Researchers at the Yong Loo Lin School of Medicine, National University of Singapore are investigating whether the biological processes of aging itself can be altered to reduce the risk of age-related conditions, including Alzheimer’s disease.”
“In a study published in Aging Cell, a research team led by Professor Brian K Kennedy from the Department of Biochemistry and Chair of the Healthy Longevity Translational Research Programme (TRP), NUS Medicine, reports that calcium alpha-ketoglutarate (CaAKG), a naturally occurring and well studied metabolite linked to healthy aging, can reverse several memory related brain functions that are disrupted in Alzheimer’s disease.”
“The researchers set out to determine whether CaAKG could improve synaptic plasticity in the Alzheimer’s brain, restore signalling pathways involved in memory, protect neurons from early degeneration, and support healthier cognitive aging overall. From a medical perspective, these findings point toward geroprotective strategies—approaches that aim to target the biology of aging itself rather than treating individual disease symptoms in isolation.”…