“The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get.
“If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.”
full text
I think there’s a lot more to this than just throwing more protein at it.
I’m not convinced that works well.
an excerpt:
At the end of the regeneration, however, extracellular matrix-related processes were the most enriched in young cells (Figure [6(c)], whereas skeletal muscle processes (i.e., muscle adaptation, contraction, hypertrophy, and relaxation) remained overrepresented in aged cells (Figure [6(d)]. A closer analysis of GO enrichment demonstrates the downregulation of these biological processes in aged (Figure [6(f)]but not in young cells (Figure [6(e)], which could explain the impaired muscle cell regeneration in aged muscle shown in the morphological analysis.
My guess is that there is a lot of junk accumulated in the extracellular matrix in old organisms and we’d probably do better to make the highest priority keeping junk from accumulating rather than putting more junk in.