I’ve been taking this for years. Mast cell go to drugs for are: rupatadine, rapamycin, and seligilne. Montelukast is nice, theoretically. I notice a big difference when I take the first few meds but I don’t notice that big a difference on montelukast.
Overactive mast cells can be a big contributor to generalized inflammation.
I was diagnosed with mass cell activation Syndrome by a neurologist years ago but I already knew what was going on. Later, I found an allergist who specialized in Mast Cell diseases and he was able to write prescriptions and code them so my insurance paid for all this stuff except rupatadine which is not FDA registered. My PCP was able to look at the codes he used and now she can get me all this stuff through my insurance as well.
"A possible treatment approach of patients with mast cell mediator release disorders would be as follows (Table 9): (1) Antihistamines (cetirizine, diphenhydramine, hydroxyzine); (2) antihistamines with anti-eosinophilic action (ketotifen, rupatadine); (3) antihistamine with antiserotonin action (cyproheptadine); (4) tricyclic antidepressants with combined antihistamine action (doxepin); (5) flavonoids (luteolin, quercetin of high purity and increased absorption); (6) antileukotrienes (montelukast); (7) cromolyn sodium; (8) steroids (methylprednisolone); (9) epinephrine (EpiPen, AnaPen); (10) anti-IgE (omalizumab), kinase inhibitors (imatinib, mitostaurine, avapritinib) should be reserved for aggressive SM or mast cell leukemiia