Royal Jelly (10-HDA): Extends the Lifespan of Caenorhabditis elegans

Interesting that it works on the MTORC pathway also.

Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.

10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling - PMC (


I am not sure their analysis on this is right. 10-HDA when it comes to Bee Queens operates through the epigenome and it is an HDAC inhibitor (if a very weak one running in the micromolar level).

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I’m not familiar enough with all this. I don’t know enough about all the science. You might very well be right.

Queen bees do live a remarkably long life compared to worker bees.

Queen honey bees live on average 1–2 years whereas workers live on average 15–38 days in the summer and 150–200 days in the winter.

A copy of the paper;

The link posted at the start the first posting above is the data images

Ask the people who wrote the paper,

Point of contact for the paper is;

*Shuji Honda:

Nagaragawa Research Center, Api Company Limited, Nagara, Gifu 502-0071, Japan

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Sakaecho, Itabashiku, Tokyo 173-0015, :japan:

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Thank you for the details, much appreciated :blush: