What senolytics did you use to counter the effects of COVID?
That is a long topic.
To keep it short we take our dietary supplement EternLFX.
The longer version (there is an even longer one LoL!)
I based the formula on the 2 Phase 1 clinical trials that demonstrated that senolytics can clear senescent cells in humans. We do not use Dasatinib in our formula.
Itās a very high dose protocol done in short cycles. I developed this formula in 2019 for personal use. It has 9 compounds, the 2 well known senolytics Quercetin and Fisetin, the other 7 are there to increase bioavailability, ease digestion, inhibit kinases and mTOR and increase blood plasma levels of the senolytics in the brain.
After seeing how it affected our epigenetic DNA methylation tests I figured it could be a good product for others. Apparently I know nothing about what consumers want, are willing to learn and are willing to spend. Some would consider that experiment to be an abysmal failure, from a commercial side.
But we continue to be able to measure benefits in ourselves and a few others who participated in a before and after type of evaluation.
We are close to 5 years of doing 4 cycles per year.
There is a lot more to increasing health span and longevity than one intervention. Senescence was something that caught my eye in 2018. Since then Iāve added a few more things to my personal longevity stack. There is no one and done, there is no silver bullet, longevity is not going to be accomplished with a single intervention, it will take many types of interventions.
After all, there are 12 Hallmarks of Aging 
1 Like
Thank goodness the effect on my eyesight wasnāt permanent although it lasted about 10 days. As of today, my eyesight appears to be mostly back to pre-COVID levels.
Whew.
But COVID is still nasty.
2 Likes
The double proline substitution causing the spike to be in its pre-fusion configuration and thus possibly making the spike inactive could help the case that the vaccine is a lot safer than the virus itself.
2 Likes
Iāve been trying to avoid COVID, but for the past 3 years, I have caught it in the March-May time period. Itās not horrible, but it knocks me out for a day and then gives me a horrible hacking cough and headache (from all the coughing) for a month or longer afterwards. Iāve been suffering through it for the past week now.
I have a feeling the vaccine would cause less damage to my body than the virus, so I think I need to get an annual booster every February.
2 Likes
We hear from a medic friend that they think the new covid in central England is not being picked up by covid tests.
2 Likes
Honestly, I think most people donāt test for COVID anymore and are just lumping it in with RSV in the flu category.
Hong Kongās health authority keeps on top of it, though, and weāre in the midst of a COVID outbreak. Of course, itās not life-threatening in most cases nowadays. Itās just damn annoying!
Also, I do wonder if coughing to the point of headache may have detrimental long-term effects for your lungs, brain and other organs much like trauma from contact sports.
1 Like
Like most viral and bacterial infections, the SARS-CoV-1 virus modifies your immune system.
The SARS-CoV-1 virus causes significant senescence in the lungs, one infection is all it takes to start this cascade.
There is no reward in getting infected by any pathogen that can take up residence for extended periods of time and continue to mess with your immune system to āhideā.
A wealth of clinical, pathological, and epidemiological observations support the notion that tissue reservoirs might be established even in asymptomatic individuals; reviews have also summarised this evidence.45,46 SARS-CoV-2 viral RNA might persist in the lower respiratory tract despite clearance from the upper respiratory tract.47 Autopsy studies have isolated infectious SARS-CoV-2 from multiple tissue types, including heart, lymph nodes, liver, spleen, and gastrointestinal tract.48,49
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00815-0/fulltext
1 Like