Conclusions
The use of a PDE5i in combination with nitrate medication in men with stable coronary artery disease may pose an increased hazard for cardiovascular morbidity and mortality. Careful patient-centered consideration before prescribing PDE5is to patients with cardiovascular disease using nitrate medication is warranted.
Full Paper:
https://www.jacc.org/doi/10.1016/j.jacc.2023.10.041
PDE 5 inhibitors:
The four oral PDE5 inhibitors commercially available in the U.S. are sildenafil (Viagra, Pfizer), vardenafil (Levitra and Staxyn, Bayer/GlaxoSmithKline), tadalafil (Cialis, Eli Lilly), and a more recently approved drug, avanafil (Stendra, Vivus). source: Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction - PMC
Nitrate Medications:
Some nitrates include:
- Dilatrate-SR, Iso-Bid, Isonate, Isorbid, Isordil, Isotrate, Sorbitrate(isosorbide dinitrate)
- Imdur (isosorbide mononitrate)
- BiDil (hydralazine with isosorbide dinitrate)
Source: Nitrate Vasodilators For Heart Disease Treatment: Uses & Side-Effects