Personally, I think the result is from its blood pressure-lowering effects. If its effects are on autophagy, there are many other supplements and drugs to take. If you are already taking a blood pressure-lowering medication and any or all of the supplements such as fisetin, curcumin, resveratrol, quercetin, green tea extract, ashwagandha, berberine, omega-3 fatty acids, etc. that promote autophagy, I would not consider switching.
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I found a seller online - looks like www.buyrilmenidine.com is expecting more stock. Not sure why I haven’t seen this site before but I’ve registered on the pricing page and will buy as soon as stock is in.
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This study is interesting, having come across this recently. Only just found someone selling this specific thing on buyrilmenidine.com, think its europe based and some places don’t require a prescription for it. Has anyone seen any further research on it since the study was published in Jan 2023? Interesting to see what further research is published on animal (other than worms!) and human trials since a year ago. Rilmenidine has been around for a while so at least it has some history behind it and appears that its use has very limited side effects compared to other medication(?)
Why would you pay $200.00?
30 100mg tablet’s cost $20.00{on 02/11/2024] with a prescription using Good Rx at ShopRite in the New York area.
Attached is a screenshot of a price search using GoodRx searching 30 X 100mg tablet’s generic rilmenidine
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That looks like a great site, but they don’t have any reference to rilmenidine or the other brands its marketed under - you didn’t include what you were searching for in your screenshot?
Go to goodRx.com, put the name in the search box and search.
You can look for generic or branded.
I have no financial interest in goodrx I do use there discount card/numbers
At time the cost using goodrx is less than the insurance co payment
FWIW:
It’s possible I suppose, but I don’t see any benefit of taking rilmenidine over telmisartan.
Rilmenidine can cause drowsiness, dry mouth, dizziness, and headache.
Telmisartan is typically well tolerated, with few side effects.
Telmisartan may have advantages over rilmenidine in terms of tolerability.
Telmisartan has beneficial effects on glucose and lipid metabolism beyond blood pressure lowering.
Rilmenidine may worsen glucose tolerance.
Telmisartan is administered once daily, while rilmenidine is typically given twice per day.
Telmisartan appears to be superior to rilmenidine overall in terms of efficacy, tolerability, metabolic effects, and convenience.
“Rilmenidine use declined in the 2000s due to concerns about withdrawal effects. It remains available but is not a first-line treatment.”
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Thanks for the additional info, @desertshores !
Just for clarity, I am not advocating one over the other. Someone asked if rilmenidine was available, I happened to come across that site so I shared it with you.
@Joseph , in the previous reply, stated rilmenidine 30 tablets 100mg but I was looking for 1mg per tablet. There is no reference to rilmenidine that I can find in goodrx or the other brands (Albarel, Hyperium, Iterium and Tenaxum), I did search on those but happy to be proven wrong.
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I concur. Telmisartan has a rate of side effects similar to placebo. So very very safe. And it seems to have incredible benefits: Angiotensin II receptor blocker (ARB) experiences? - #25 by adssx
Given the current data we have, I see no reason to choose anything else than telmisartan.
(disclaimer: I’m about to start telmisartan 20 mg to fix my elevated BP)
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I assume the scientists studying Rilmenidine have a sound basis for their focus and optimism, and I note that their publications are appropriately qualified. On the other hand, a few of the usual media sources have prematurely claimed benefits to humans, some in an exaggerated fashion.
For the time being, I’m going to stay on the sidelines for the following reasons:
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As someone who takes a large number of supplements daily, including those focused on life extension, I am mindful of the potential for adverse interactions among combinations of supplements including the possibly irreversible kidney and/or liver damage. I don’t see this as a large threat, especially when framed as a risk/benefit equation but I acknowledge that I am operating in largely uncharted waters. This is one of many reasons why I am thankful for the information we share in groups like this one.
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It would be difficult to put a precise number on it but the number of medical research studies on C. Elegans that end up generalizing well to humans is quite small. Numbers have been placed on the percent of medical research on mice generalizing to humans and they start around 5-10% with none being much higher. This is not to detract from important animal research, only to note that its primary benefits to human research are to suggest and refine specific paths of inquiry.
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Someone may point out a better way to look at my last reason for remaining on the sideline, but I wonder why Rilmenidine is available in so few countries. I also see Rilmenidine listed on the EU(7)-PIM list of potentially inappropriate medications for older people (consented by experts from seven European countries). This lack of availability could also run the other way. I recall the US being something like 30 years behind the curve in approving metformin.
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@adssx I began taking another sartan (Losartan) recently for borderline hypertension. The results greatly exceeded my expectations. I hope your results are as good. Initially, you may see a modest reduction in BP but it can take a month or more to see the full effects. My BP was in the 135-140/80 range, higher in the morning and lower in the evening. Not terribly high but I wanted to move into a healthier range. After a month, my BP has dropped to a low reading of 104/68 and a high of 124/75. Most of these reading were taking across different times each day within a minute or two after sitting down. Close enough.
To get this kind of result with no side effects of any kind was a surprise. When taking a sartan, you want to be vigilant about excess potassium intake and monitor your blood potassium one you have stabilized on the medication.
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Exactly… just because something shows promise in worms, doesn’t mean its going to be effective in humans…(I suspect most don’t pan out, in fact most mice studies don’t translate to humans)… still lots of testing to be done, in mice, then in humans.
As an aside, Matt Kaeberlein has commented in the past that people making decisions to take something based just on worm (c.elegans) studies, are absolutely and completely premature… its way too early.
Amazing! Thanks for this report. I’ve just bought an Aktiia device to have my BP 24/7 and see the result before/after. I’ll report the outcome.
By the way, which dose of losartan are you using?
50 mg./day with evening meal.
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Is there a home use device that can reliably monitor potassium levels (either by blood like glucose monitoring/ or with urine test strips)?
I was wondering the same thing @Walter_Brown. I found a few mail-in test strips, such as to LabCorp, but I wasn’t able to find a simple on-the-spot urine test strip. If K is significantly elevated, it will recycle through the kidneys and urine. In turn, that will probably alter PH, which is easily measured on many urine test strips, but I don’t know if that route of inference has much specificity. For now, I’m forgoing bananas but otherwise eating my same Mediterranean diet until I get my regular Life Extension blood test. I have read that elevated serum K is a greater concern when there is significant kidney impairment and/or a high sartan dose.
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In worms…
Previous research has shown rilmenidine mimics the effects of caloric restriction on a cellular level. Reducing available energy while maintaining nutrition within the body has been shown to extend lifespans in several animal models.
Whether this translates to human biology, or is a potential risk to our health, is a topic of ongoing debate. Finding ways to achieve the same benefits without the costs of extreme calorie cutting could lead to new ways to improve health in old age.
In a study published in January, young and old Caenorhabditis elegans worms treated with the drug – which is normally used to treat high blood pressure – lived longer and presented higher measures in a variety of health markers in the same way as restricting calories, as the scientists had hoped.
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What about rilmenidine vs viagra?
I read many articles before I switched from losartan to telmisartan, Telemsarten also has longevity effects and fewer side effects than rilmenidine.
“What should pleasantly surprise members taking antihypertensive drugs now is that telmisartan has displayed longevity benefits above and beyond its ability to control blood pressure 24 hours a day”
So, I won’t be switching to ranitidine at this time. I might reconsider in the future if there are any real benefits to switching from telmisartan to ranitidine
“Telmisartan reduces the risk of dementia & cognitive impairment”.
“Telmisartan recommended over rilmenidine due to better evidence for cardiovascular protection”
“Of all the drugs in this class, telmisartan stands out as superior for potential longevity enhancement.101-103”
“Why Telmisartan Is Best For Blood Pressure - Life Extension”
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