Repost of a review which was taken down on reddit (not my review)
My honest review of Folligenz 10% Liposomal Minoxidil Sulfate
I bought a few bottles of the 10% and kind of regret it. I’m not sure if they fixed the bottles so I may be giving outdated information but it’s basically unusable and there are tons of crystals in the solution which they claim is not the minoxidil itself but rather the shea butter or something they used to make it less irritating for the scalp. No amount of shaking reduces the crystals or makes the problem better. Given how minoxidil above 5% likes to crash out of solution I’m not entirely convinced their statement about what the crystals actually are is truthful and I’ll get to why I don’t trust their word as the post goes on.
The dispenser sucks quite frankly. It might be the crystals clogging things up but I can barely get any of the product out… or, randomly, it’ll shoot out like 0.5mL all at once and start running down my face and stuff. I had to cut the tip of the dispenser off to get anything out after I’d used a bit of the product (the solution to crystal ratio got high enough that nothing was dispensing). That sort of helped, but it was still hard to get product to come out. The top isn’t removable btw and they don’t recommend cutting the tip off like I did but there was no other way.
After the hassles I experienced with it I gave up after only using like 1/3 of my first bottle (I bought 3…). It just wasn’t worth the hassle. Went back to using my homemade mix of minoxidil, dutasteride, melatonin, and tretinoin.
I would really recommend avoiding. The guy behind it all has amassed a following from covering hair loss stuff and sharing his theories and now he’s selling products all of a sudden. That should’ve been a red flag to me. The people who follow him kinda just blindly follow everything he says (he’s a huge reason why there’s so many PP405 haters now) and it’s kind of reminding me of what happened with jumpman/pegasus2 if anyone knows who that is. The guy doesn’t have any more hidden knowledge or secrets than we do and it’s not wise to put people on a pedestal in this area of research.
His discord is very quick to shoot down things like PP405 while also hyping things like stemoxydine which has been on the market for like 10+ years at this point and we know does next to nothing. Conveniently, he plans to sell stemoxydine soon. I tried talking about my experience with PP405 from anageninc and everychem and my messages kept getting filtered by a bot in the server. I tried rephrasing my messages to exclude mentions of competitors and instead focus on the molecules themselves - still censored. If he can’t market it he doesn’t want you talking about it (because he’s afraid of infringing patent law, which is probably the only admirable thing about the whole practice). The guy is almost surely a grifter.
I will probably get downvoted by his followers for posting this but it’s my honest experience with the product and observations of past patterns from other people in this space as well as in his YouTube and Folligenz discords. I did a little digging after writing most of the body of this post and found that they supposedly fixed the dispenser/crystallization issues but I don’t have a ton of faith at this point. My bottles of the original design arrived basically DOA. And the stuff isn’t exactly cheap either, $255 for a 3 month supply is insane for a product that literally isn’t usable. There’s no possible way he spent any significant time with his own product and didn’t run into this issue himself. So either he didn’t bother to use his own product, or he knowingly sent out a defective product. In either case it does not fill me with hope that the claimed fix is actually a fix.
Regarding PP405, the phase 2 results presentation did not mention hair counts which tempered expectations amongst the community. There is a need for a growth stimulant that can activate hair follicles in the hairline and crown that even a decade or more on traditional treatment can’t recover but it’s doubtful for now whether PP405 can deliver on that.
I do agree with the assessment that the person behind Folligenz is bordering on grifter territory though.
All great points on PP405. Should also be noted KwRx was a big part of why it got so hyped in the first place.
But I do want to push back a bit on this.
Selling an ill-conceived product is one thing, actively using intimidation tactics to take down bad reviews like the one I reposted firmly crosses into scam territory.
We can completely stop and somewhat reverse hairloss since at least the 90s. The difficult part is restoring hairs that have either died already or are so damaged that they can’t grow on their own anymore.
There’s plenty of folks resilient to 5α-reductase inhibitors and/or minoxidil.
I think what you mean to say is that we can slow down hairloss.
Also, finasteride loses efficacy over time and dutasteride is linked to metabolic syndrome. Systemic minoxidil carries a serious cardiovascular risk profile, which to some seems moot, but yea, no cardiac remodelling for this cat.
Maybe some microneedling pain sessions? Won’t work if you actually have longer hair. Tretinoic acid? Peeps using this may actually get worse hair loss.
The Italian, Japanese and South Korean long term studies point to 90% or more of people maintaining their hair over 5-10 years with finasteride/dutasteride. Combine that with new topical AA and close to 100% of men with AGA will have their hairloss halted.
As for topical minoxidil, it’s true that only around half of men respond well to it. With extended-release oral minoxidil coming out soon, that figure will rise to 90% or higher.
Using both methods, almost every man will be able to grow hair.
Also, finasteride loses efficacy over time
There are people who have been on it for over 20 years now and most report either maintenance or slight thinning/recession when they were likely destined to be NW7 by now. And that’s just with the weakest 5ar inhibitor on the market.
I don’t get it, do you mean a hair transplant?
No, I meant growing hair in places with either only vellus hair or no hair at all. PP405 was supposed to do that but results so far are underwhelming.
yes man, but it doesn’t cure hair loss, it just slows it down bro. I’ve been on these compounds for many years. The fin does lose efficacy, so I switched to dut, but my LDL is rising, so I am cutting back to 1ce a week dut + 6x 2.5 mg fin. I’m not touching mino.
My hair is still there but its much thinner twenty years later, so it didn’t stop it.
I appreciate that it slowed it down, and even if it didn’t, I personally believe the destruction of DHT is a good thing, so I will keep it up. I think I will prob go back to dut after a while.
Anyhow, that’s my own experience, and I read many times a lot of people have similar results.
Also, one good site for this kind of research is Hair Loss Cure 2020, although 2020 is long gone, the site is still active. I linked one of their newer reports (on Clascoterone).
We haven’t solved aging yet so slowing hairloss by well over 90% means that you’ll effectively have hair your entire life and that’s with just finasteride.
My hair is still there but its much thinner twenty years later, so it didn’t stop it
You’d be bald 17 years ago without fin. If there was any other compound that slowed aging as much as finasteride slows/stops hairloss, the average life expectacy would be 1,000.
Also, one good site for this kind of research is Hair Loss Cure 2020, although 2020 is long gone, the site is still active. I linked one of their newer reports (on Clascoterone).
Clascoterone is a welcome addition but likely not enough as monotherapy. It stacks well with 5ar inhibitors and once it goes generic in 20 years, I’ll probably add it to my stack.
you don’t know that lol. All my brothers still have lots of hair and none of them use those compounds.
I’m not too argumentative these days and accept each to their beliefs. I know what these drugs do and what they don’t.
It’s 2026 and we haven’t cured hairloss (ie. reversed the damaged follicle !) and yet we think we can tackle aging (like by using NMN instead of nicotinic acid !).
Edit; to be honest, I like the idea of senolytics regarding future therapies. I still hope for extending life, but completely curing age… this will take a while to figure out.
You just had the misfortune of having balding genes.
It’s 2026 and we haven’t cured hairloss (ie. reversed the damaged follicle !) and yet we think we can tackle aging (like by using NMN instead of nicotinic acid !).
We know the root cause of MPB and can pretty much prevent damage. We don’t know the root cause of aging and at the upstream there might even be several causes that all need to be addressed at once.
Edit; to be honest, I like the idea of senolytics regarding future therapies.
If you catch it early enough and/or are lucky enough, then finasteride can bring you back pretty good in most cases. Around Norwood 4 is roughly when response becomes much lower.
Circling back to the Folligenz product, their website contains virtually no documentation related to product stability or the purity of the active ingredient.
Minoxidil sulfate is notoriously unstable, as this reviewer discovered. The company appears to have made a band-aid to the formula but I would suggest waiting a few months for confirmation that it’s actually fixed - their claimed cause of too much stearic acid barely passes the smell test.
And it seems unlikely that they were able to fix the formula and create new batches, import from Brazil to US, all in 3 months having actually done any real stability testing.
Almost all useful information is locked in their discord, seemingly by design. Talking about this in public is met with a vicious reaction from Kwaku Ampadu, the company founder.
watch out, assumptions and all. The same can/can’t be said regarding aging.
Do telomerase activators increase mice lifespan indefinitely already? Last I heard they extended it by 10% or so.
Why don’t you explain why you feel that way>
Because a) not all senescent cells are bad, b) senolytics failed in various trials like the ITP and c) cell potential is not a limiting factor for aging (yet).
Given the lack of actual hair count changes in the treatment and placebo group, this thing is likely a (much) weaker regrowth stimulant than minoxidil and can at best help strengthen a few hairs on your hairline that aren’t quite invisible yet but also won’t grow terminal on their own even on dutasteride.
i beg to differ. less telomeres on many diseased tissues.
its thru a completely different mechanism than androgens. My point is that there is much more to learn. And to declare that we have figured out hair loss, I think we still have a ways to go. I ordered some of that sh*t this morning btw. My hair is still ok for my age, but it ain’t like it was when I was 25, that’s for sure. I’ve never used topicals though…
They’re a pain. 90% of topical minoxidil users quit within 1 year. It’s split into mostly 3 reasons or combinations of reasons:
Inconvenience
Poor response
Irritation
In the context of this thread, the Folligenz Liposomal Minoxidil Sulfate product is designed to overcome 2 and 3, but has virtually no evidence for being able to do so and isn’t very shelf-stable.
But ultimately oral minoxidil has become the real answer to all 3 and is dirt cheap and safe.
I don’t mind fin and dut, but I have been playing hopscotch between them in the last couple months. I don’t like the idea that they are associated with metabolic syndrome, and being that I was solely using 0.5 dutasteride each day, I thought to take a break and use fin for a while instead @ 1mg AM and 1mg PM. I still use 0.5 dut once a week though.
The only reason I said I’d try the makebelieve PP405 is that it’s suppose to regen zombie follicles, so theoretically, you would just pulse this product and not need to use it forever. Personally I don’t think it’ll do anything.
