For me this looks like nothing more or less than an other advertorial.
Cannot find a study protocol with methods, inclusion criteria etc.
Doing separate trials can have valid reasons but can also be a method to avoid negative results on one outcome to take down the substance for all indications.
The text states testing for safety. So even after this the question of result remains open.
We’ve been discussing “cholinesterase inhibitors” in many aspects of longevity on our forums for the past year or two. This is the first I’ve seen with regard to hair repigmentation:
Re-pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population
Eighty consecutive Chinese patients diagnosed with Alzheimer disease were assessed for darkening of grey hair. Of the 62 eligible patients (mean age = 79.3 ± 7.9 years; male: female = 1:1.48), 24/62 (38.7%, 95%CI: 26.6 – 51.9) reported hair darkening after prolonged usage of cholinesterase inhibitor for at least 6 months. Of the 24 patients with hair darkening, 17 (70.9%) experienced hair darkening in the occipital region, 3 (12.5%) in the parietal region, 2 (8.3%) patients in the frontal region and 2 (8.3%) patients experienced hair darkening in multiple regions. Analysis of melanin concentration showed no significant difference between darkened hair of patients after prolonged drug use and the dark hair of controls (P = 0.381).
Paywalled article summary:
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.13356
Full Paper PDF here: Sci-Hub | Re‐pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population. Australasian Journal of Dermatology | 10.1111/ajd.13356
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I agree. Clearly a fairly yukky smell after applied. The ingredients include sulfur.
Any idea which one and what does they are using?
Did you quote a different post than you’re replying to?
Sorry. First post on this forum.
I was posting about GR-7. Don’t know how I got turned around.
GR-7 did work for me. But some gray areas–the ones which had been gray for the longest time–are slower to get back color like the other areas on my head have.
The smell, as I said, is a bit of a bummer. You don’t smell it when just smelling the product. It seems to be only after it is on one’s head a while. Sulfur is listed as an ingredient, and I guess it is an approximately sulfuric odor–though not exactly.
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Came across this, sounds rather interesting but not any Info I can find as just patent
Also https://areygrey.com/
I heard a dermatologist say on a YouTube video that none of GR-7, Arey, or Mayraki had done controlled trials unfortunately, at least not yet.
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Just to confirm risks of long-term ingestion of finasteride: a few men posted on the longecity.org website that they personally experienced anhedonia, ED, and/or other adverse effects after long-term ingestion of finasteride or saw palmetto. Do a web search for “post-finasteride syndrome” to learn more. Or go to About Post-Finasteride Syndrome – The Post-Finasteride Syndrome Foundation
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If you search on reddit, people have claimed to have gotten PFS/PSSD from even supplements such as Ashwagandha. I tend to not trust people’s claims because many of them, especially on the internet, are either hypochondrics, liars or would’ve developed ED naturally (tadalafil/sidenafil wasn’t invented to treat finasteride and antidepressant side effects).
Besides that, your source is a litigious organisation. In one of the trials against Merck by the PFS Foundation, the FDA stated as following.
In 2017, the Post Finasteride Syndrome (PFS) advocacy group petitioned for a stop to selling of the drug or advertisement of stronger warnings. The US Food and Drug Administration (FDA) had advised that the PFS petition “does not provide reasonable evidence” of a link to suicide, but in August 2022 added suicidal ideation (SI) and behaviour to the adverse reactions listed for finasteride. According to the FDA statement, the PFS petition “does not provide reasonable evidence” of a causal link between finasteride and persistent SD, depression, or suicide. However, on the basis of reports from patients using the 1-mg dose for AGA, the FDA is “requiring the addition of SI and behaviour” to the listed AEs.
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I saw a thread on reddit where one person said that finasteride made him hear voices. I wonder what else he hallucinated.
ED from finasteride is real however, although rare, and most cases as far as I understand resolve after drug cessation. This doesn’t mean these people aren’t genuinely suffering, it’s most likely not from finasteride though, and that ‘community’ isn’t helping them at all.
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Dutasteride is safer than finasteride. Make sure to take tadalafil before bedtime to ensure the penile tissue stays well-oxygenated throughout the night.
Our study showed no increased risk of suicidal behaviour in the general population of men treated for BPH with finasteride relative to those treated with dutasteride, particularly, among men without psychiatric disorders. However, among men with a history of mood disorders, we found that finasteride may be associated with a higher risk of suicide death and severe self-harm with the use of violent means or admission to an intensive care unit than dutasteride.
Biological evidence on the impact of finasteride on suicidal behaviour is very scarce57. Biological studies have instead investigated the mechanisms involving finasteride or 5α-reductase inhibitors in the development of depression, including alterations in neuro-steroid levels (notably allopregnanolone), dopaminergic dysfunction, reduced hippocampal neurogenesis, increased neuro-inflammation, alteration of the hypothalamic–pituitary–adrenal axis, and epigenetic modifications58. The increased risk of suicide death or severe self-harm among men with previous mood disorders treated with finasteride relative to those treated with dutasteride could be explained both by an increased suicidal risk with finasteride, as well as a protective effect of dutasteride59. It is not possible to distinguish between these two hypotheses with the data used for our study. Finasteride is known to cross the blood–brain barrier and thus can affect concentrations of neuro-steroids and their metabolites in the cerebrospinal fluid16,17,18,60,61,62. It is not currently clear to what extent dutasteride also crosses the blood–brain barrier and further biological investigations are needed to address this issue, as such a difference could explain the difference observed in our study between two drugs of the same pharmacological class. It cannot be excluded that dutasteride is also associated with an increased suicidal risk for at-risk individuals.
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According to the evidence found, dutasteride shows great neuroprotective, antioxidant and anti-inflammatory effects. It also appears effective against glutamate toxicity, and it is capable of restoring altered dopamine activity (DA). These effects are achieved both directly and through steroid hormones. Therefore, dutasteride seems to be a promising molecule for the treatment of ALS, although clinical studies are required for confirmation.
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Yikes, I didn’t know all that. Thanks.
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Someone recently organized a group buy for a Japanese treatment. I suppose we’ll find out if it actually works next year.
Where did you see the buy group? Please post info if you can…
FYI- thus far, that GB is not exactly going swimmingly. Still very up in the air as to whether its going to actually take place in some satisfactory manner.
Can you share what the issue is? Number of buyers, technical difficulties, etc.?
I would be very interested if there was a way to validate the compound, and the purity via a third party independent lab here in the US. Perhaps we do a group buy of the validation - everyone pitch in $50 towards getting a lab to validate it is what they say it is, and the purity of the samples.
One of the issues I suspect is that its hard to get a reference standard (the known chemical that can serve as the reference standard to do the comparison against). Sigma Aldrich doesn’t seem to provide it:
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I sent RapAdmin a PM, but mainly the issue is having possible trouble with the lab.
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Hey bro, do you have telegram?