Very interesting. Thanks
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So you used it only on gray hair?
I don’t really have a lot of gray hair, starting to get some strands, I kind of like it sometimes especially in summer when sun bleaches my hair is really good but in winter it gets more visible… maybe I will try it. Costs around 40 EUR… if it is tyrosine only as active ingredient maybe a DIY solution is viable? What do you thing @Agetron? 
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You rub it into your scalp. I can’t be certain that the only active ingredient is tyrosine, it’s just that I read that it’s crucial for melanin production. They currently have a Black Friday sale of about 15 percent off right now.
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What is the product/ brand name of thedutasteride?
I’m puzzled.
Either it’s a dye, which binds to and colours the hair shaft.
Or it switches on melanin deposition inside the shaft as it grows.
But, if it’s a dye, surely it should work on everyone? This seems to work on most customers, but to varying degrees and some unlucky people have no results. (Going by product reviews.)
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It’s a clear liquid so it’s not a dye per se, I think it’s stimulating the hair bulb to produce melanin. The hair goes yellow before your natural color comes back in.
It does say on the website that results vary depending on what caused the grey hair. I really wasn’t expecting much, but my grey has completely gone. That said, I didn’t have all that much.
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Tyrosine supplementation may also help
Looks like there are potential interactions between Tyrosine and mTOR:
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Ingredients:
Aqua, Isopropyl alcohol, Glycerine, Biotin, Ammonium Chloride, Inositol, Ammonium Acetate, Palmitic Acid, Polysorbate 20, Tyrosine, Burdock Root Extract - Articum Lappa, Gallic Acid, Sulphur, Horsetail Extract, Parfum.
I checked the ingredients and marked the possible active ingredients. Since Ammonium Acetate is usually used in less than 1% in hair and Ammonium Chloride is used in 1% concentration in hair leave in products this gives some idea about composition.
Anyway, I ordered first bottle on promotion, 15% off 
, will report back.
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I can’t tell you how it works because I honestly don’t understand it. But it doesn´t replace the melanin from the roots because if you have gray hair and you use it for a few days the greys will disappear, but it isn´t that the hair grows without gray hair but rather the hair that was white a few days before is now your original color.
One way to test it is on the beard, if someone has gray hair and uses it and then shaves, when it comes back they should no longer have gray hair, but I doubt that is the case.
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Here is another l-tyrosine based grey hair restoration product for the DIY minded HydroSal® Hair Color Restoration
L-tyrosine is a non-essential amino acid that occurs naturally in your body and produces melanin, the pigment that determines skin and hair color. L-tyrosine taken as a supplement may help prevent graying and return hair to its original color.
Research shows that gray hair is caused by a buildup of hydrogen peroxide in the hair shaft, a natural occurrence in aging. When the hydrogen peroxide accumulates, it damages the melanin responsible for giving hair its color. The higher levels of hydrogen peroxide that occur as a result of lower levels of catalase reduce levels of tyrosine as well, inhibiting its ability to produce melanin.
Hair Anti-Aging Conditioner Formula
| Ingredients | (W/W %) |
|---|---|
| HydroSal® Hair Color Restoration | 2.00 |
| HydroSal® Hemp | 1.00 |
| Oryza Sativa (Rice) Extract | 2.00 |
| Glycerin | 3.00 |
| Behentrimonium Chloride | 4.00 |
| Cetearyl Alcohol | 1.50 |
| Glyceryl Stearate | 0.50 |
| Cocos Nucifera (Coconut) Oil | 1.00 |
| Squalane | 3.00 |
| Argania Spinosa Kernel Oil | 3.00 |
| Helianthus Annuus (Sunflower) Seed Oil (and) Rosmarinus Officinalis Extract | 0.50 |
| Phenethyl Alcohol (and) Pentylene Glycol (and) Propanediol 1.00 | 1.00 |
| Fragrance 0.20 | 0.20 |
| Water (Aqua) 77.50 | 77.50 |
That one on amazon has a pretty similar composition to GR7: ANTI GRAY HAIR FOR MEN AND WOMEN - tyrosine natural - gray hair color
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It’s just replacing the pigment on the hair follicle. It’s not permanent but it’s flooding the hair-shaft with tyrosine, which is what is present in a hair with a functional hair bulb. It’s a dye in the sense that it is mimicking the contents of a healthy hair.
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Certain types of anabolic steroids are DHT-based. This type of steroid will increase muscle mass. It will also cause balding in anyone with a propensity towards male pattern baldness.
Anyway, I don’t think we can say it has no role in adult males. Increasing the levels (together with strength training) does result in increased muscle mass. It is not an inert substance.
I have no idea what it would do in adult women, but … probably not a good idea!
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The paper says: “The 20-week study of 102 healthy men examined the effects of high-dose (2.5 mg per day) dutasteride (a 5α-reductase inhibitor) and testosterone enanthate compared with placebo and testosterone enanthate. […]. Each arm was also subdivided into four dosage branches based on the testosterone dose given (50–600 mg per week).”
600 mg per week of testosterone…!!! In a medical study. Wow. That is a dose that a steroid using body builder would use while on cycle. Who would expect muscle mass reduction in that scenario? Even at 50 mg per week, probably most men won’t see any reduction in muscle mass over 20 weeks.
I would not expect suppressing DHT for 20 weeks while administering testosterone would reduce muscle mass. I would anticipate an increase in muscle mass at the higher dose, and no observable effect in such a short period in the lower dose.
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Sounds good. I do like my tonic.
I went off my hooch tonic for 5 months… and loss my gains… fine thicker hair. Went back on 3 weeks… and yep…it does grow hair and it gives me a color that’s natural to my own color.
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I guess it would make sense that they could develop it to work in that way. I think also of note is that it’s developed by Northwestern University who have done a lot of work with PAI-1. So it may become a research focus area for them. Good find @AndyR00.
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I wonder what form the sulphur is in?
(Some users have commented on the smell.)
Elemental?
H2S?
I use the product Dutasteride AB. AB stands for Aurobindo, the pharma company. It’s a 0,5 mg soft capsule which a gel like liquid
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Thanks for this info. I have my 23andme data and will try if I can do something with this first. What advice did they give you based on your genes?
Exogenous DHT is a different story than the DHT we produce ourselves.
Would you care to colorize this statement?
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