Me too! I loved Adderall. A doc who prescribed it for me retired, and the others in my orbit are less pharmaceutically inclined. Modafinil, by comparison, is worthless. Unfortunately, I haven’t noticed any mood- or focus-enhancing effects from fairly high doses of SS-31.
3 Likes
Can you describe the difference between Adderall and Modafinil?
1 Like
Modafinil supposedly promotes wakefulness, but unless you suffer from a sleep disorder such as narcolepsy, it probably won’t do much. At best, it’s a mild stimulant. When pulling all-nighters, which I still like to do even in my seventies, I find that it’s no better than caffeine.
Now, when the U.S. bombed Iran last year, the pilots were said to be popping Modafinil on their 36-hour, round-trip flight. I’m sure that this is true, but we don’t what dose they took, and we don’t know what other meds they were ingesting. My guess is that the military has a whole top-secret pharmacy at its disposal.
Adderall is far more powerful than Modafinil. Providing a huge hit of serotonin and dopamine, it intensifies concentration and elevates the mood. It is great for taking on either the most mundane or the most challenging of tasks. It is also an appetite suppressant, which can lead to its abuse. One drawback of Adderall is that, from my perspective, it raises body temperature, which means that it can lead to overheating.
Speaking of the military, amphetamines like Adderall were distributed to soldiers on both sides in WWII, Korea, and VietNam. This helped them to overcome physical exhaustion, battle fatigue, and even fear of dying. They had pills to psych them up and pills to bring them down. Who knows what they have available to them now.
3 Likes
I’ve been kept up over 36 hours straight when I took 250mg of armodafinil. Never took it again after that.
3 Likes
It does have a long half-life, but it works differently for you. I can go to sleep on it after 12 hours or so.
1 Like
I think I am going to switch from Reta to tirzepatide. I’m kind of tired of this massive bump in resting heart rate and I’m hearing that it is far less pronounced with Tirzepatide. I’ll probably just do 2.5mg of Tirz and leave it there since i’m not really trying to lose weight and I don’t want too much appetite suppression. 2-3mg Reta spikes it 20bpm
2 Likes
Some of us are welcoming the increase in metabolism and compensate for it with statins and SGLT2i.
1 Like
I beg to differ
1 Like
I’m sorry to hear this @Tim ! I was hoping it would help others more than just me.
I don’t know what I’m talking about, but because you aren’t seeing the same thing, I wonder if it is more about if someone has more damaged mitochondria to fix than their ADD? Or, it just works on people differently, similar to many other things? Just spitballing here.
Also, I posted about this somewhere else the other day, so I’ll have to try to find it to make an edit, but I thought I’d share my one day of having super duper energy after a double dose appears to have been a fluke, sigh. I skipped a dose and then did it again and nothing magical happened.
3 Likes
For me even low dose mondafinil is like crack - manic energy, euphoria, racing heart, no sleep the whole night no matter when I take it, etc.
4 Likes
For me, tirz was better for appetite suppression at low doses and also didn’t increase my HR as much as reta, BUT it came with significant fatigue/lethargy as a side effect. If you can get the appetite suppression without the fatigue, then I’d go with tirz for sure.
5 Likes
For me (and I know I’m going against the grain on this one a bit lol) taking GLP1’s other than to lose weight and perhaps to manage diabetes is not worth the side effects. Both Tirze and Reta (never tried Ozempic) made me lethargic to the point of not wanting to do anything i.e. take the garbage out in front of the house (i literally had couple garbage bags full in my kitchen floor for few days), plus I lost a lot of muscle, and my strength dropped by more than 50%. In addition, my rested HR increased by about 15 in both cases (reta and Tirze) and I have to assume it cannot be good either. As far as losing strength as an example if I were doing 100lbs on a machine, all I could do after taking glp1’s was 50lbs. Initially I was scared like hell that I may never be normal self again but thank God for HGH and now maraviroc and my motivation is back to normal, and my strength has also come back to my normal levels pre glp1.
I initially thought I’d be taking a small 2mg dose for life (for supposed additional benefits) but have since changed my mind and will only take glp1’s when I need to lose weight and hopefully never (As I’ll try to manage weight by other means).
3 Likes
You’re certainly not alone. The large inter-individual variability in side effects with this class of compounds never ceases to amaze me.
6 Likes
Why is it you think Tirzepatide could cause more lethargy? Lack of a glucagon receptor?
1 Like
I don’t think anyone can answer this confidently since there are quite a few people who get lethargic with reta as well (although anecdotally it does seem less common with reta).
2 Likes
I just know I’m excited for my heart rate to hopefully drop back down the 15-20bpm it went up. I’m getting kind of sick of this after I dropped Ivabradine since I felt it was impacting my fitness level as someone who does HIIT.
3 Likes
This will be an interesting case study in heart rate differences between the two.
1 Like
Glucagon helps burn more energy at rest, I imagine this is why it gives more energy and is more muscle sparing. Probably contributes to higher heart rate as well.
1 Like
I can’t remember if we’ve discussed this newer study on this forum, but the results are a bit surprising. Orforglipron is associated with the greatest increase in HR (even though it’s a pure GLP-1 agonist) and tirzepatide the least. And the difference between tirz and reta is an average of just 1 extra beat per min:
3 Likes
12mg/week Reta and my RHR went up 8 BPM, but after a couple months maintaining that dose only up 5-6 BPM from baseline. Tirz up to 13mg/week maybe had a 2-3 BMP increase.
4 Likes