Resetting the aging clock through epigenetic reprogramming: Insights from natural products☆

#1

https://www.sciencedirect.com/science/article/abs/pii/S0163725825000622

Abstract

Epigenetic modifications play a critical role in regulating gene expression under various physiological and pathological conditions. Epigenetic modifications reprogramming is a recognized hallmark of aging and a key component of the aging clock used to differentiate between chronological and biological age. The potential for prospective diagnosis and regulatory capabilities position epigenetic modifications as an emerging drug target to extend longevity and alleviate age-related organ dysfunctions. In the past few decades, numerous preclinical studies have demonstrated the therapeutic potential of natural products in various human diseases, including aging, with some advancing to clinical trials and clinical application. This review highlights the discovery and recent advancements in the aging clock, as well as the potential use of natural products as anti-aging therapeutics by correcting disordered epigenetic reprogramming. Specifically, the focus is on the imbalance of histone modifications, alterations in DNA methylation patterns, disrupted ATP-dependent chromatin remodeling, and changes in RNA modifications. By exploring these areas, new insights can be gained into aging prediction and anti-aging interventions.

Sadly behind a paywall.

#2

Do you know where to get the full text of this?

#3

Ask and thou shalt receive!
1-s2.0-S0163725825000622-main.pdf (1.5 MB)

That said, I don’t think the article is that great, to be honest. There’s some typical AI drivel (IMO), and shallow mentions of resveratrol, curcumin, catechin/EGCG, quercetin etc - all based on cell studies or limited mouse studies.

I have published two papers on this temporary reprogramming stuff (using actual OKSM reprogramming factors) and while I think it has some potential, we’re a long way away from being able to actuate it for therapy of anything IMO. Right now, you need drug-inducible genetic mutant mouse models, or you need viruses to carry the reprogramming factors. The risks are also super high. If you reprogram too much, you de-differentiate cells and they lose function (i.e. in heart, it stops contracting, oops), and there’s risk of teratomas.

Even then, the reprogramming rate is low and the efficacy isn’t that great. I love the concept of this, but it’s so incredibly implausible to me that curcumin or green tea is going to do anything even close to the real deal.

1 Like
#4

I will have a read through when I get some time. I find at least it does mention acetylation (of the histone) as well as methylation (of the dna). No mention of splicing, however. (Although one reference mentions it).