I stopped taking curcumin after someone posted it activated CYP 3A4 which breaks down Rapamycin.
“Sirolimus is known to be a substrate for both cytochrome P-450 3A4 (CYP3A4) and p-glycoprotein (P-gp). Inducers of CYP3A4 and P-gp may decrease sirolimus concentrations whereas inhibitors of CYP3A4 and P-gp may increase sirolimus concentrations”
https://www.pfizermedicalinformation.com/en-us/rapamune/dosage-forms
I just found that berberine is inhibitor of CYP3A4.
Conclusions: Repeated administration of berberine (300 mg, t.i.d., p.o.) decreased CYP2D6, 2C9, and CYP3A4 activities Drug-drug interactions should be considered when berberine is administered.
https://www.nature.com/articles/srep06587
I still take berberine and after reading it decreases CYP3A4 activities, I may resume combining it with curcumin. I’ve read more than one study showing as soon as you stick effect from combining berberine and curcumin for Alzheimer’s.