Repeated administration of berberine inhibits cytochromes P450 in humans

#1

I stopped taking curcumin after someone posted it activated CYP 3A4 which breaks down Rapamycin.

“Sirolimus is known to be a substrate for both cytochrome P-450 3A4 (CYP3A4) and p-glycoprotein (P-gp). Inducers of CYP3A4 and P-gp may decrease sirolimus concentrations whereas inhibitors of CYP3A4 and P-gp may increase sirolimus concentrations”
https://www.pfizermedicalinformation.com/en-us/rapamune/dosage-forms

I just found that berberine is inhibitor of CYP3A4.
Conclusions: Repeated administration of berberine (300 mg, t.i.d., p.o.) decreased CYP2D6, 2C9, and CYP3A4 activities Drug-drug interactions should be considered when berberine is administered.

https://www.nature.com/articles/srep06587

I still take berberine and after reading it decreases CYP3A4 activities, I may resume combining it with curcumin. I’ve read more than one study showing as soon as you stick effect from combining berberine and curcumin for Alzheimer’s.

https://www.researchgate.net/publication/339413674_Synergic_Effects_of_Berberine_and_Curcumin_on_Improving_Cognitive_Function_in_an_Alzheimer’s_Disease_Mouse_Model

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#2

I use Berberine, Curcumin, Pterostilbene and Quercetin as a quartet of HDAC inhibitors. When I take Rapamycin I aim to take it before the HDACi quartet.

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#3

It seems like one of the downsides to Rapa is its long half life. Are you trying to extend that?

#4

I take it infrequently because of its half life. I take the HDACi s for their effects. Not on rapamycin.