- Skeletal muscle NAD content moderately declines with aging.
- Regular exercise upregulates NAD synthesis in both young and aged muscle tissue.
- NAD precursor supplementation strategies are less effective than exercise training in staving off muscle and systemic aging.
I’m finding that in many cases, supplementing with a molecule is a suboptimal strategy compared to exercise. The first question I usually ask myself these days is usually: yes, but how does that compare to exercise?