Reducing Lp(a) with enobosarm/ostarine

#1

Just thought I’d post an update on my successful “n of 1” research study in which I’ve decreased my Lp(a) from nearly 200 down to 25 with a low dose of the selective androgen receptor modulator enobosarm (also known as ostarine). Enobosarm is an orally bioavailable compound currently in stage 3 trials for muscle wasting and for lean mass preservation during GLP therapy for weight loss. Previously I mistakenly attributed my decreased Lp(a) to IGF-1 LR3.

Most recently I reduced the dose of enobosarm from 6mg/day down to 3mg/day (the conservative dose used in clinical studies), expecting reduced efficacy but instead my Lp(a) is now the lowest it’s ever been. Note the zig-zags up and down are from stopping/starting/stopping/restarting enobosarm:

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NOTE: enobosarm/ostarine is not yet FDA approved and is only available as a research compound, which is not labeled for human use and depending on the source could be of poor quality and/or have contaminants, so buyer/user beware.

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#2

Any impact on ALT or HDL? ApoB?

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#3

No effect on ALT or ApoB, but ApoB is already well controlled with meds. I take TUDCA every morning with the enobosarm just to mitigate any potential effect on liver enzymes. I don’t bother checking HDL these days since it appears basically irrelevant when ApoB and Lp(a) are low.

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#4

Your LP(a) fluctuates greatly currently and you only have 1 data point before taking ostsrine which could have been taken when you had one of those high peaks.

I bought some ostarine a couple of years ago but never dared take it btw

#5

How much did it reduce your hormones?

#6
#7

Impressive. I have sky high Lp(a), but SARMs as a remedy are too adventurous for my pedestrian self. I think I’ll wait for the dedicated Lp(a) drugs currently trialled. Of course, more power to you - you’re a braver man than me!