I was reading about how using EGCG present in tea extends the median lifespan of rats +13% by protecting their liver and kidneys.
When I remembered this contradicts what have been found in the ITP using Green Tea Extract. So diggning a little bit deeper I run into this study:
The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride
It looks like there are plenty of compunds that can be an advantage early on and they may bring some disadvantage later in life. Too much green tea seems to be one of those.
“Three drugs that had been identified to extend lifespan using the log-rank test no longer had statistically significant effects according to the Gehan test: acarbose in females at 400 ppm and 1000 ppm (Fig. S2A and S2B), butanediol in females (Fig. S2C), and glycine in males (Fig. S2D)”