RapaPro vs generic Sirolmus

Hello I’m new to the group but have been reading and lurking, not posting.

I bought my first batch of Rapamycin without a Drs prescription from a source that I’ve used over the years for other prescription products. I got RapaPro and used the 6mg once per week protocol.
Side effects were mouth sores, faster heart beat, etc.

After a couple of months I was able to convince my local physician to write a script for generic Sirolmus and switched over to it a few weeks ago.(same dose, etc)
I am not feeling anything and have no side effects at all.
Could my body have just adapted or could the US prescription be the problem?

I’m just seeing what others here have experienced?
I did take yesterday’s dose with grapefruit juice so I’m hoping that will help a bit.

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RapaPro is not the opposite of generic Sirolimus.

That is Rapamune by Pfizer.

I would avoid RapaPro:

As promised, I have an update on my RapaPro from AAS. I took 2.5 mg of RapaPro for 12 days. My repeat Ramamycin shows that there is no Rapamycin at all in the pill I received. I asked for a full refund, and I received a nice reply from the company saying they would send one. I will report back when it arrives. Sadly, because I took a fake drug, my potentially life-threatening autoimmune conditions have been untreated for two months. The only advice I can offer after my experience is that you must have A mechanism to prove you are getting what you have been sold. In my case, my life was in jeapordy because of this. It might not just be money you are wasting! :cold_sweat:

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That’s where I bought my batch. How do you know for certain that it didn’t contain Rapamycin? Like I said, I had the side effects associated with it and am now not getting those with a US prescription?

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I don’t have the burden of proof.

The generic rapamycin you are getting with a prescription is real however.

To not have any side effects is good.

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If you’re making the statement that “there is no Rapamycin at all in the pill I received” then the burden of proof is with you because you’re making this accusation. Did you get it tested at a lab?

  1. Avoid RapaPro because they have sold pills without rapamycin and in the past not tested their products

  2. The generic rapamycin they are getting with a prescription is real.

These are my statements.
I don’t know if it’s fake or real, but I do know generic rapa is real.

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Can you tell from the packaging what “brand” (the manufacturer) of the generic sirolimus is? Glenmark? Dr. Reddy’s?

Is it a tablet or is it a capsule (i.e. gelcap)?

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It’s a small white tablet

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Hmmm… my rapamycin, rapamune, sirolimus and now Zydus is beige to olive green… never white.


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When I search Pill with S1…
I don’t get a rapalog medication.
Am I missing something. Easy enough to Google.

Came right up

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My bet would be that its fine. This is a drug typically used in organ transplant patients. If it was not in the range of the correct dosing/bioavailability then the transplant patients would likely know pretty quickly…

https://www.ascendlaboratories.com

https://www.ascendlaboratories.com/Home/ProductDetails?NDC=67877074701

RapaPro has had quality issues in the past, but they may have corrected the issue now.

Most people don’t get any side effects with rapamycin… so that alone isn’t going to tell you much.

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Thanks for the responses.

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Apologies for the late bump, and if this was covered already. IIIRC, the “bad batch” of RapaPro from a few years ago was compounded for them in Greece. And to the company’s credit, they did acknowledge the issue and offer refunds. (Mind you, I had already bought some from the very next batch, and unfortunately the company did not respond to my query about whether they could confirm the potency of that batch).

The current RapaPro product is made in India (information obtained from the Profound Products website). I assume they simply have one of the Indian generics packaged specifically for them? Still may be general issues about bioavailability that seems to affect many of the generics (susceptibility to stomach acid etc.), but hopefully the Rapamycin content itself trustworthy now (or as trustworthy as the Indian generics in general).

Ascend Laboratories LLC. makes that its 1MG and is FDA approved should be just fine taking that.

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I agree w/ @RapAdmin on this - as I have many patients who have opted for RapaPro, it’s the one I use, and it has for the last 18 months consistently tested consistent with stated ingredients on sirolimus levels. The issue now, as I mentioned this to a new patient the other day - is that this group isn’t shipping to the U.S. right now, presumably due to tariff issues.

The only reasons I see to get offshore currently, is if you cannot get a doctor here to Rx it to you, and importantly, IF you haven’t sorted out life/health insurance long term (can even get denials of Medicare supplemental policies) before starting this and having a U.S. pharmacy record of you taking it - do so first. If you cannot do this, getting off-shore is probably wise, as no amount of letters from me on your behalf or claims you were taking to avoid aging will convince anyone you don’t have some horrible condition, and they won’t insure you.

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