So from your perspective, the dosing range should be between 6 and 36 mg. That does seem to make sense. I wonder if that would be altered by taking Metformin or Acarbose as the negative side effects may be mitigated by those?
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Oh definitely not as high as 36 mg. I was at that level for 7 monthsā¦ and lost the great age reduction benefits from previous 1 1/2 years at 6 mg.
My recommendation is to keep the dose between 6mg and 12.mgā¦ current my dose for the past 5 months
I know that 6 mg the standard for many on here is effective at least in my tests.
It was at the higher dose numbers - where I lost benefit.
I wonder what biomarkers suffered from the higher dose numbers?
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Perhaps a higher dosage already inhibits stem cells. And this, depending on the condition, can be both beneficial and harmful
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Visited our old friend Aging.Ai today to update any progress I am making from taking rapamycin. This is the first time this test gave me a better result than before I started taking rapamycin. I hope that their learning model is becoming more accurate. In any case, it does give a sense that I am doing some of the right things.
Todayās inputs based on recent tests gave me a 14-year age reduction, 68yrs as opposed to 82yrs. But hell, who wants to be 68? 
Start early my friends and keep that 35-year-old body. 
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Good results! Congrats! Thereās nothing wrong though with 68 btw if you keep at least a 40yo body. Iām totally happy with my 68 
- the whole purpose of taking rapamycin is to age chronologically but not biologically.
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FYI - My blood panels and total blood tests (4 pages) all stayed the same the 7 months.
Only the glycans on my proteins and DNA methylation changed. But that is important. Just want to caution on very high dosing.
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Yes, my bloodwork improved after I stopped with the higher doses. I am now (I might change my mind next week) taking 5mg weekly.
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High dosing will maintain a level of inhibition that probably isnāt helpful.
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This result made me seriously doubt the platform. Iām 58 (nearly 59). It predicted my age at 20.
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Could be an error. But my greater interest is in your health protocol, if you would be so kind to share.
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I am now experimenting with putting the Biocon/Rapacan pills into some enteric-coated capsules that I bought. I have a script to get a rapamycin level check at my local Lab Corp, but they have such a poorly run office you donāt how long the wait will be to give a blood sample.
Basically, I have just been procrastinating. I think using the enteric-coated capsules would be less variable than the grapefruit juice. If the capsules donāt at least give some multiplication advantage I will go back to using grapefruit juice
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Good for you. While I donāt have any idea if their age predictions are accurate, they are based on a very large sample base and use AI and the submission of actual age after the test to continually update the accuracy. In any case, it is a fun thing to do to monitor your health progress, and best of all itās free.
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Most importantly, I go to the gym 3-7 times a week. I use 18/6 time-restricted feeding, take rapamycin, and a few of the most popular supplements that claim to be age-extending.
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Iām not quite sure how to answer that. I have a lot less protocol than many people here. But I have been a pescatarian and non-simple carb eater since about 1985. So my diet is essentially fruit, vegetables, hard boiled egg whites (and one yolk a day) and fish a few times a week. I sort of do time-limited eating. I donāt eat breakfast but eat lunch and dinner. I have almost no added fats in my diet (I donāt buy any of the keto fanaticism.) From my experience, fat becomes fat in my body āas does any amount of simple carbs. But because of all the fruit and veg in my diet, I get tons of complex carbs without needing to add starches. I think the lack of added fat is what accounts for my extraordinarily good lipid and cholesterol numbers (total cholesterol 143).
I was a professional dancer until my mid-20s, then a fitness athlete and then a competitive triathlete until about 5 years ago. But after 3 spine surgeries and some other orthopedic stuff, I donāt compete anymore since more than a little bit of running has become risky for the future of my spine. But I still workout about 90 minutes a day. 60 minutes of cardio (I swim, water jog, cycle depending on the day) including about 15 minutes of high intensity anaerobic threshold intervals. I do some strength training about 2 or 3 times a week. Not tons.
Other than the current Rapamycin regimen (6 mg once a week, 17 weeks so far), the only supplements I take are for specific functions or for things that have periodically been low in my bloodwork. So, glucosamine-chondroitin (for arthritic joints), DHEA because my testosterone skews low and I canāt tolerate very much of it without breaking out, D3/K2 and Bacopa (because thereās some data showing it helps maintain cognitive function). My bloodwork doesnāt reflect any change since beginning the Rapamycināand I detect no change in my experience other than pimples emerging in odd places (albeit not enough to dissuade me).
Other than that, I drink rarely.
Thatās it.
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Thank you.
Regimen is time tested and doable - pescatarian (Japanese), complex carbs (Japanese, Okinawan, Loma Linda Adventists), HIIT (science-based).
Rapamycin, am still on the fence.
The only part not doable by me is the dancing - two left feet.
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I just tried aging.ai. I got a predicted age of 29 (Iām 60).
This one gave me 48yo so it is much more realistic. Itās also free.
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Joseph, you may be killinā it! Of the calculators that I have tried, I think Longevityās is theoretically the least accurate. Why, because it uses the least number of variables and does not indicate what their database (at least as far as I could find) is. On, the other hand, the Levine-derived calculator and aging.ai both have large databases. Aging.ai has arguably the largest database and is constantly updating. I donāt what your overall health or fitness routines are, but you are obliviously doing something right. IMO: the Levine-derived calculator is the most accurate of the calculators using just normal blood sample results.
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Awesome! I also did the photo-based assessment. It nailed my age exactly.
I do work hard to stay fit, and my daughters tell me I donāt have a ādad bodā. So thereās that.
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