Purpose (the aim of the study): Mechanistic target of rapamycin (mTOR) signaling has been implicated in the initiation and progression of osteoarthritis (OA) and biological aging. Treatment with the mTOR-inhibitor rapamycin (Rapa) can extend lifespan in several model organisms including mice. mTOR-inhibition can also attenuate post-traumatic OA pathology in some studies using young, inbred male mice. However, this effect is not unanimous across studies, and the impact of mTOR-inhibition on OA pathology in naturally aging male and female mice has not been investigated. Therefore, to determine if long-term systemic mTOR-inhibition can attenuate age-related OA pathology, we examined the knee joints of genetically heterogeneous male and female mice receiving dietary Rapa or placebo starting during adulthood until natural death.
This might be a good place to mention I took a month off Rapamycin (to see if it would drop my A1C) and my gym aches and pains seem to have returned. I was wondering why this could be then thought it could be the lack of Rapamycin. I’ll be starting again next week.
I haven’t gotten A1C tested again yet, but this is the first subjective noticeable thing I can say I got from Rapamycin (assuming it’s the cause) by discontinuing it.
I haven’t tested but find when I’m on rapa breaks my running aches act up. Not documented but pretty sure of the correlation and will track going forward….
Btw the running aches are new territory for me have only been running for less than two years…and surprisingly race very well I believe due to my diet, supplements, cryo, saunas, hbot, etc. along with tracking tools (oura, garmin) that have made the journey a fascinating, engaging game. Also learned runners high is real IMO.