I know this is highly speculative, but I’m interested in whether anyone on this forum has taken Rapamycin as a means to treat a dilated aorta? Especially due to genetic conditions like Marfan syndrome. There’s some interesting studies in mice Rapamycin being protective of aneurysm/dissection…
https://www.jvascsurg.org/article/S0741-5214(18)31780-4/fulltext
Or this study which reversed aortic dilation in mice by inhibiting iNOS and speculates Rapamycin may be appropriate in humans since it works via a similar pathway…
https://www.embopress.org/doi/full/10.1038/s44321-023-00009-7
As a possible mechanism: various connective tissue disorders that result in aortic dilation share elevated levels of TGF-beta. And TGF-beta is predicted to activate mTOR.
Seems very curious to me but no idea if it’s a subject that’s been explored by others? Thanks!