It would be very interesting to create a simple survey with different questions around peoples experiences with rapamycin and based on that data plot out it in an anonymous way to the matrix. Maybe we could write a follow up research study as the one Matt Kaeberlein did some years ago (pubmed: 37191826)
Here are some potential questions to the survey. Have I missed something or should some questions be rephrased or removed? All feedback is welcome!
What is your age?
What is your gender?
What is your height?
What is your current body weight? (please specify whether it is kg or lbs)
Do you have any medical conditions? (For example autoimmunity, transplant recipient, cardiovascular disease)
Which brand of rapamycin are you using? (For example: Rapamune, Dr. Reddy’s, generic versions, etc.)
How many milligrams of rapamycin do you currently take?
How frequently do you take rapamycin? (For example: Daily, weekly, every other week, etc.)
Do you take rapamycin continuously or do you have any special on and off cycling period that you use?
For how long have you been using rapamycin?
What motivated you to try rapamycin?
Have you observed any beneficial effects? (Rate each effect with mild, moderate or strong)
Have you observed any adverse effects? (Rate each effect with mild, moderate or strong)
Do you have any thoughts on why rapamycin worked or did not work for you?
Do you think any lifestyle factors (e.g., diet, exercise, sleep patterns) contributed significantly to either the beneficial or adverse effects you experienced?
Please share any other observations, comments, or potential explanations regarding your rapamycin experience.
If you have adjusted your dosage or regimen over time, how did your beneficial and adverse effects change?
Perhaps it’s worth including the lab results of those who have tested incase it’s valuable to see how much is in the system of the various individuals (including how long after their dose their blood was drawn).
@Karel1 Very great point! Here are some more questions that I will add thanks to your feedback!
What time of the day do you take rapamycin?
Are you taking rapamycin on an empty stomach or with food?
If you take it with food, do you take it with grapefruit juice, oily food or something else which increases the effective dose?
@Beth Very interesting to include lab results as well! I like it but it will require some work to consolidate that date from all people but I really like it. It would be worth doing it. Thanks for the feedback!
Well, that’s a problem in general, isn’t it? Some of us are not present on social media for a variety of reasons. I myself am on pretty much nothing, not x (twitter), not facebook, not instagram, tik-tok etc., not for any ideological reasons at all, but out of simple calculation that all these are time sinks, and that it’s super easy to get caught up in giant time commitments where once you’re sucked in, you feel compelled to continue sinking ever more time into this. So, from the beginning, I consciously avoided all these like the plague - even going back to ancient stuff like friendster, and myspace - I was always aware of stuff very early, like when twitter started, because I follow tech developments pretty closely, knew about google as they were starting out, snagged a cool gmail address for my wife in the first closed sign up period before it went public etc., but I was careful to never commit to any social stuff. Believe me, it creates problems! Like many companies or workplaces expect you to be on FB for example, or you cross the border and they expect you to have a media presence they can peruse, and are super suspicious if you tell them you don’t have any - makes it sound like you’re hiding something, lol. I spend my posting and internet interaction time right here on rapamycin.news for 90% of the time, and casually on a couple more sites, but that’s it.
So yes, it’s going to be hard for folks like us - social media avoiders - to coordinate anything. But it can’t be helped - I will never sign up to FB, x, etc. - life’s too short.
@dlkmd@CronosTempi
Curious question, what is it about this survey that made you think it has something to do with that you need an account on X? The reason I mentioned X was because I sketched on the phenotype responder matrix and published a first draft there but also on different social media channels. So no one does not need to get a social media account to be part of this upcoming survey.
When it comes to social media channels overall then it would be very hard to get funding for the research I’m trying to push forward if I would close down my accounts. Most of the funding, connections and partnerships has come thanks to social media interaction. So currently I need to be out there to keep up the speed on things. Let’s see how things develop in the future.
In my experience the autonomic (dys)regulation and sleep quality could be key determinants for phenotyping rapamycin response.
Personally, I have completed 9 cycles of rapamycin administration, each lasting 11 days (aiming more for body composition improvement than longevity). No change in heart rate, but a rather clear change in HRV pattern over the 11 days. Mean values below.
No acute effects on sleep despite administration at bedtime.
All data derived from a smart ring. I suggest placing greater emphasis on sleep quality and HRV in the matrix / survey. These metrics could serve as important indicators of physiological response. Additionally, while changes in skin temperature appear small, they are consistent in my case and might also hold value. Collectively, these parameters may prove to be early biomarkers of successful rapamycin use over time. Perhaps they could also be used for dose adjustments.
Big thanks for sharing this! Do you also have data on how it looked like before you started taking rapamycin? I’m very curious to see how those different measurements were impacted by rapamycin.
It’s very interesting also that you are thinking that some of the measurements could be used to dose protocol adjustments. I’m also looking at this topic. Let’s have an online talk about it. I will send you my calendar and we can discuss this more in depth.
I have not yet evaluated the long-term effects of Rapamycin (pre- vs. post-9 cycles) on these metrics. I suspect the changes are minor (unlike for body composition). However, I have analysed how weekdays versus weekends influence the measurements—for example, I tend to sleep a few hours more and consume slightly more calories on weekends. Apart from HRV, the changes across metrics are small or negligible. Data are mean over 35 weeks.
These HRV values look like ones from a fitness tracker. I think it is a good idea to take HRV at the same time each day (I do it lying in bed in the morning) using an ECG. I use Polar H10 plus Elite, but that gives a materially different result to fitbit. The tracker AFAICS only tracks HRV when asleep.
The data come from a cheap smart ring. In the past, I’ve used devices like the Polar H10 and analysed the results using the Kubios software platform. Over the years, I’ve come to realize that sometimes it’s better to keep things simple and focus on collecting a large number of data points to help offset random measurement errors.
I’ve stopped doing morning HRV measurements because it’s difficult for me to interpret abnormal readings. For example, it’s unclear whether an abnormal HRV value is due to non-stress-related poor sleep or increased stress levels—it’s a “chicken or egg” situation for me…
As for Rapamycin’s effects on HRV and heart rate, I seem to experience the opposite of what most users report. I suspect Rapamycin isn’t suitable for everyone, which is why identifying biomarkers to predict individual responses is so important. That’s why I support Krister’s work in this area. How are your readings influenced by rapamycin, John?
Rapamycin is only one of a number of interventions I use and I have not particularly tried to isolate out any effects on HRV. I record every morning both the fitbit hrv and the polar H10/elite HRV. However, I don’t carry those values forward into my spreadsheet although I have the records for some time.
There are big effects on HRV from from alcohol (I am an intermittent binge drinker) and whether I am in the parasympathetic or sympathetic state.
I had a session recently where I switched up perhaps 10-20ms or more hitting at a peak 84ms. I have not worked out precisely what caused this although I have suspicions. For those that don’t know I am now 65
To me it is an interesting value, but hard to extract useful information from as it moves around quite a bit anyway (and is heavily influenced by some factors).
These are Elite’s stats more generally.
The last time I took rapamycin (a high dose) was 28th Feb, but I also then got drunk (1 bottle white wine and 3 pints bitter) as this sort of counteracts the sleep disruption.
Fitbits hrv was quite low at 17ms and Elite more normal at 62ms.
The next night I also got drunk and fitbit was 49ms and elite 61ms.
The next night I was drunk and fitbit failed to read and elite was 48
Then I did not drink at all and fitbit was 45ms and elite 58.
The reason the alcohol does not seem to damage hrv on elite as much as you would expect is because my autonomous nervous system was in the parasympathetic state.
That in essence is why I don’t think I can extract useful information as to the link between Rapamycin and HRV even if I stop drinking for a few days the balance of the ANS will still have a big effect.
On the other hand the recent session I had of even higher HRV is something I am aiming to replicate.
