Hello, many of us are purchasing Rapamycin tablets via mail order and even from overseas. Last week when I received my shipment it was about 38 degrees C outside. I imagine the shipping cargo area can get much hotter. On the medication container it says not to store at a temperature above 30 deg C. I opened a strip and the medication looks fine. Is anyone aware of any stability issues with the tablet form of rapamycin at extreme temperature ranges that could be experienced during shipping?
I don’t know about the issue of short term temperature exposures, but:
Here is what the Pfizer website says:
Rapamune Oral Solution bottles should be stored protected from light and refrigerated at 2°C to 8°C (36°F to 46°F). Once the bottle is opened, the contents should be used within one month. If necessary, the patient may store the bottles at room temperatures up to 25°C (77°F) for a short period of time (e.g., not more than 15 days for the bottles).
Rapamune Tablets should be stored at 20°C to 25°C [USP Controlled Room Temperature] (68°F to 77°F). Use cartons to protect blister cards and strips from light. Dispense in a tight, light-resistant container as defined in the USP.
Tablets I believe are far more stable than solution, which is far more stable than powder. It has to do with how the molecule is stabilized (or not) in it’s unique formulation.