I have been thinking about starting rapamycin for so long, but somehow never pulled the trigger. I have this notion that rapamycin pushes toward catabolism, and I seem to be very catabolic by nature.
I have severe osteoporosis. Recently I went back in to my Promethease report and saw that I have two risk alleles on each of two SNP’s that modulate the WNT16/catenin pathway – which controls bone remodeling, specifically bone formation. This was truly a Eureka moment for me because it means I need to take a a relatively new (and very expensive) monoclonal antibody, called Evenity, (romosuzumab) that reduces sclerostin. (The genetic risks mean I create too much sclerostin in the bone osteocytes).
Before this I was on track to start a different med, but my endocrinologist (after consulting an expert on this issue) agreed to prescribe Evenity. Now need to persuade medicare, which should not be a problem as the T score is so, so bad.
But the reason for this post: I looked at rapamycin and sclerostin-- and it turns out that rapamycin can cause a higher production of sclerostin. It does the opposite of what Evenity does.
So, my sense that Rapamycin was not a fit for me personally has been borne out.
Also learned that sclerostin can cross the BBB and potentiate the development of Alzheimers. Another biggest worry, and family history of both AD and osteoporosis/hip fractures just increases my anxiety about what to do.
Just putting all this out there in case anyone is dealing with any of these issues. Would welcome feedback.