Interesting, not much new here given that this id what GLP1 agonists do, they regulate leptin levels as you lose weight. I think there’s even human studies that show this. Here is the interesting part :
Although several new incretin-based therapies have shown potent effects on reversing obesity, it is likely that other therapeutic approaches will be necessary for managing obesity in patients who cannot tolerate these drugs or fail to respond to them, or to help maintain weight in patients after treatment.82,83 Overall, these data suggest that selective inhibition of mTOR in POMC neurons could provide an alternative therapeutic strategy. The development of brain-specific rapalogs provides a possible means to selectively reduce mTOR activity in the brain, and it might also be possible to develop cell-specific mTOR modulators.