A new autophagy / rapamycin paper focused on over training:
In conclusion, rapamycin appears efficiently to increase the autophagy proteins and decrease IL-6 protein in the liver of overtraining mice.
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I feel I’ve felt this. I lifted weights 7 days in a row a couple weeks ago and my Oura ring did not pick up on over training. My resting heart rate was normal. Typically, prior to rapamycin, 2 days of training was sufficient to raise my resting heart rate 10 beats per min.
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