Rapamycin plus Berberine

Anyone else supplement Berberrine even though A1c is normal? Any issues with rapa and Berberrine?

Currently no evidence that Berberine is worth taking.


I thought impact on glucose and lipids pretty well established?

I supplement with Berberine. My A1c is lowish. What it would be without any Berberine I don’t know.

Berberine is another HDAC inhibitor.

I take Acarbose with Rapa.

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Berberine will possibly increase the levels of Rapamycin in your body. Berberine is poorly absorbed and quickly metabolized.
Im not a big fan of Metformin in non diabetics, but I think Metformin is better than Berberine. Better studied, more reliable doses and massively more experience in its use.