Hugely important…IF your intent of course is to get the full Cmax/AUC boost of GFJ.
Do a Sirolimus blood test sometime, trough level at minimum before next dosing.
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For those who missed the study on GFJ:
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This is incredible, you’re an example for us all. You don’t have any wrinkles!!
My dad is 72 and looks older.
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Wow - you look fantastic for your age, and I doubt you’ve been on the Rapa long enough for it to have had much an effect yet.
I reckon you’ve got decades ahead of you.
I’m guessing you are the oldest person on this forum so you are a trailblazer for the rest of us.
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My best suggestion to avoid wrinkles is to avoid exposure to sunlight. To give yourself proof of this, examine the skin of your inner thighs compared to your outer forearm and lower front neck. I live in the desert and had excessive exposure to sunlight and developed chronic actinic keratoses on my scalp and was told by my dermatologist to avoid as much sunlight as possible. I take vitamin d supplements and use red light therapy to compensate for my lack of sunlight exposure.
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Would absolutely concur. My 82 yr old mom who shuns the outdoor UV, has skin of someone < 50, almost no wrinkles on her face/body. Some 60 yr Floridian shun worshippers I know look like crepe paper.
I’m 70, been taking 6-8 mg/week for about three years. In terms of weight loss, Dr. Green believes if you lose weight while taking rapa your set point doesn’t go down, so your base metabolism is still high. Normally when you lose weight your set point goes down so you can gain weight on the same number of calories you used to consume. I’ve lost 50 lbs (from 235 to 185), and it’s easy for me to stay at this weight without worrying about calories. I just focus on protein grams (P:E diet principles).
Exercise-wise I’ve found that I can exercise harder and have almost zero post-exercise soreness or stiffness. I’ve found it more challenging to add muscle (though I am getting stronger) but that probably has a lot to do with my age and with finding it challenging to eat enough protein. I’m going to really concentrate on progressive overloading now so that should help (it makes me hungrier as well!)
Diet-wise, I was basically on a ketogenic diet when I lost most of the weight. I recently focused more on protein and “slow carbs” (e.g., beans) and cut out any other carbs (other than wine), and lowered fat intake, and dropped 7 lbs. and 1-2% body fat in a couple of weeks.
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Charles - good to see you here again. What is your workout routine? How many times a week, for how long? Resistance exercise (e.g. weights), or cardio?
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I do a HIIT training session on a Schwinn Airdyne 2-3 times a week (one easy, two more intense). I do resistance training with kettlebells a couple of times a week, though I’m going to increase my resistance training over the next few weeks. I don’t do any cardio as such, though both the HIIT and the resistance training work the cardiovascular system. I don’t do any Zone 2 training because I can’t find a way to do it that doesn’t cause overuse issues with my knees.
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Has your blood work shown any impact on RBCs or hemoglobin? I note a couple of doctors expressing concern over anaemia…
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Yes my RBC and hemoglobin have continued to drop since taking rapamycin. The most recent test results were taken after 3 months of high dosage rapamycin. The latest results might be skewed because I donated blood two weeks before the tests. Definitely, something to keep an eye on. I think my RBC is on the low side as I donate blood on a regular basis.
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What month/year did you start? Don’t those graphs show an immediate drop followed by a steady recovery (with the noted exception of the most recent data point)?
I started in October 2021
Ah ok, that’s quite significant then
Desert Shores……from previous posts it looks like you are in great shape and got there on 10 mg. So what is reason to double to 20?
In general, my question relates to the fact that many people on here post good results…sometimes great….on 6 mg and then increase to 12 or even more. I understand doing that if no results in some reasonable period at the lower dose, but not so much if one gets good results.
I understand that there may be effects that are not really noticeable that might come at higher doses, but guess that given the unknowns might be better off with a pot of gold rather than trying to heap more on. But again, that is personal preference, I guess.
I experimented with a higher dose, 20mg with grapefruit juice, to get a high peak dose to increase the amount that crosses the blood-brain barrier. Rapamycin does not cross in significant amounts in low doses. That, and the fact that I was already old when I started rapamycin, I believe that I have to take higher doses to get any significant anti-aging benefits.
I certainly would not recommend this dosage for younger people. 20mg with grapefruit juice is too high for me as I experienced unpleasant flatulence and diarrhea at this dose.
On my next round, I am going to cut back to 10mg every 2 weeks.
Where is the info on dose and blood brain barrier?
First I have heard with raps. Familiar with the concept.
Might be that older people need less to make a difference.
Point is my take is outside of the BBB stuff it worked for you at the lower dose.
Rapamycin has a molecular weight of 914.17,
“Generally, only lipid soluble (lipophilic) molecules with a low molecular weight (under 400–600 Da) cross the blood-brain barrier Possible strategies to cross the blood-brain barrier. Possible strategies to cross the blood–brain barrier | Italian Journal of Pediatrics | Full Text
Note” 1 Da = 1 g/mol.
This is an extremely important article in my opinion of the many neural benefits of rapamycin and the aspects of BBB
Rapamycin may have a distinct advantage over previous and current neuroprotectants
https://journals.sagepub.com/doi/10.1177/0271678X18807309
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This indeed “might” be Rapamycin mediated, although it was only 2 weeks after blood donation.
Seems your regular donations has you skirting just above (and sometimes below) mins.
I have been doing phlebotomy every 8 weeks for years (another hack), and went back and checked my CBC when captured soon after a donation (whilst on Rapamycin). No significant drop in RBC/Hemoglobin.
Anemia is a high prevalence side of effect of higher dosing Rapamycin. In the Sirolimus/GFJ cancer study, 46/138 reported, and 5/138 grade 3/4 toxicity.
Any classic symptoms of anemia?