Rapamycin (or acarbose/empagliflozin) and waist circumference

yup, been drinking almond for years, no gut issues at all and its very yummy! especially with oatmeal :slight_smile: If you’re a heavy dairy milk drinker, you might not like it at first but after a week or so you get use to it.

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All plant milks are heavy processed foods and by definition very unhealthy. Do as you wish but personally I would let drink plant milk ONLY my worst enemies lol

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Plant milk is not necessarily heavily processed. There are some local farms that make it along with tofu.

Hey Jensen… yes, I take even on low carb meals… I think Matt Kaeberlein mentioned there could be more benefit then just preventing glucose spikes from carbs. Not enough research yet. So, I take on all meals.

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I think it makes sense to take with all meals, unless you’re literally just chugging olive oil. People have the misconception that Acarbose is just an alpha-glucosidase inhibitor, but it also inhibits pancreatic production of alpha-amylase, and we know even small amounts of resistant starches in food improve health. Most real meals have some amount of starch in them, so I think it is worthwhile.

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I’ve been on it for about 3-4 months and have lost 2 pounds. Like you, not trying to do so. And now that I think about it, it seems I am cinching my belt one hole tighter.

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I am just finishing (as a subject) the year-long PEARL clinical trial using Rapamycin, where one of the principal endpoints is visceral fat, as measured in a DXA scan. I have seen a 30% drop in total-body visceral fat, from about 3.3 lb to 2.3 lb. I haven’t noticed a reduction in waist circumference, but visceral fat is deep within your body, around stomach, liver and intestines (and having less of it is definitely better).

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How frequently do you exercise?

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During the last 6 months when I’ve seen most of this drop in visceral fat, my exercise has been very limited, due to an arm injury and the pressures of running a business. I do manage a small number (~50) squats per day while doing other things, and I’ve been getting out for a walk or hike at best once a week.

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I have been taking acarbose for a year. There is no weight loss for me. I also have been taking rapamycin for pprox, 3 years now

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Nice to know. Just started Acarbose. With Rapa my weight is stable and the same for years, but no matter how much I eat I have difficulty gaining weight.

Could you please pass that problem on to me :rofl::rofl:

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Many doctors and scientist are fond of debunking the association with genetics. My lifetime of observation tell me different. I was skinny as a child and have never had a problem losing weight if I overendulged for sometime. Yes, diets have a huge effect, but IMO it is also true that gentics plays a big factor in how hard it is to gain or lose weight. We all have some problem areas.

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