Rapamycin + Metformin

#101

@desertshores and I see others are taking metformin in the PM. Any reasoning for not AM and in the PM?

Tnx curt

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#102

It depends on how much metformin you are taking. If you are taking more than 500 mg of metformin, I would divide the dose.
My 500 mg prescription says evening.

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#103

I take mine in the evening as well. When I was taking 1 g, I split the dose between morning and night. I actually switched to Metformin XR which slowly releases metformin throughout the day in order to avoid GI issues. It’s a little more expensive though.

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#104

I had a strange reaction between jardiance and metformin… Might just be a coincidence. I’ll restart tonight with 500mg xr. My cgm does not go below 5…

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#105

Something I don’t see others stating in this thread is metformin helping with asthma.

  • Most studies show reduced asthma exacerbations (fewer ER visits and hospitalizations) in people taking metformin.
  • Benefits are likely due to anti-inflammatory effects via AMPK activation, not just blood sugar control.
  • Animal studies support this too, showing reduced airway inflammation and remodelling.
  • GLP-1 agonists may further enhance asthma control when added to metformin.
  • SGLT2 inhibitors perform similarly to metformin, while DPP-4 inhibitors may be less helpful or even worsen asthma control.
  • No studies in my review showed harm from metformin in asthma patients. Only one showed mixed results and called for more research.
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#106

Does that include sustained release versions?

Vogue and L’Oreal were not on my longevity bingo card. This is why you don’t gamble.

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#107

There are many drugs and supplements that have anti-inflammatory effects via AMP activation, from aspirin to quercetin.
Oddly, after decades of taking metformin, I began having diarrhea after taking it, even in the extended-release form, so I am no longer taking it.

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#108

We’ll see how I go with it.

#109

“The paper also highlights other relevant pathways: inhibition of NF-κB signalling, suppression of vascular smooth muscle cell senescence, reductions in reactive oxygen species and improved lipid handling via PCSK9 modulation. These mechanisms appear to converge on structural benefits – reduced arterial stiffness, slower plaque formation and improved endothelial integrity – all early markers of vascular aging with known links to mortality”

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