Describing a multi-function drug as dirty just doesn’t make sense. Many vitamins and other supplements are multi-function. Why call them dirty? Here is another example of the “dirty” drug metformin’s multi-function:
“Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice”
“Here, we show that combination treatment with metformin ameliorates negative effects of rapamycin while maintaining its benefits”
IMO: This is an important article to read fully for those taking rapamycin. It addresses the increased lipids and increased blood glucose levels in some subjects taking rapamycin.
That is a great article. It’s too bad that many people don’t read these articles fully.
Is there a mention of the proper dosage of Metformin per mg of Rapamycin?
He just says that because it has multiple effects on the body and pathways. Matt K would say the same about fasting. One of the things he likes about rapamycin is that it only affects MTor. I can see how that would appeal to a scientist who has to worry about confounding factors. I am happy to take a “dirty” drug!
The power of combinatorial approaches in aging.
shows how some drugs can synergize with metformin to increase lifespan in C. elegans. Proof of concept for his spin out
Latest argument against metformin dosing for non diabetics. I tend to agree. However since Rapamycin creates Rapamycin diabetes and based on the ITP data, I will still take metformin before switching to acarbose when I run out of metformin.