Ugh.
I’m finding more interactions as I research.
I take luteolin several times a day and Fisetin once. They are very important supplements for me—and inhibitors. Most supplements that are on the lists are things I’ve already dropped or that I could try skipping for a couple of days. But luteolin is crucial for me.
Argh.
I just want to thank everyone for this invaluable thread and add some more.
I’ve been systematically researching interactions with every supplement I am on.
It’s not possible for me to get off every supplement that interacts with rapamycin, but this could help explain why it’s been so hard to get ON rapamycin. And it also may not be advisable, with these supplement interactions, for me to go up to the full dose (currently, I’m at 4mg/weekly), since I lack a careful doctor’s oversight and testing.
One thing I’ve learned is that rapa can effect potassium levels—can both send them low or high—which could be tricky for me as someone who already needs to take potassium. But maybe this is not a concern with the low doses we are on?
There are a couple of supplements I will now stop and some I may try to reduce from every day to a few days per week until I’ve used my stash. Others I absolutely must keep.
Back when I had a functional MD, he really stressed getting me on trans-reservatrol, pomegranate, biocurcumin, and pterostilbene for conditions I have. These all seem to be significant inhibitors.
Vitamin Ks hold potential to mess up CYP3A4!
I did remove green tea and ashwagandha before getting on.
Pycnogenol can be an inducer (which maybe I should actually keep to balance inhibitors, if balancing has any relevance to this topic?). Fisetin is an inhibitor.
Luteolin is vital for me and not one I can drop altogether. I take it 3x a day, so I could try to get away with magnolia bark instead a couple of evenings per week. The only way I could drop it is with an MD willing to prescribe large doses of cromolyn (which I should probably be on regardless but lack access to) and insurance that would cover it (which I also do not have).
Aloe Vera, which I must take for Ehlers Danlos, can affect CYP3A4.
Magnesium glycinate, which I must take, can alter the activity of CYP3A4.
Apparently tart cherry is fine, but my year’s supply happens to also include grape seed, which is not, sigh.
Sea buckthorn is an inhibitor.
Selenium can have an effect.
Different strains of probiotics can affect CYP3A4, but I will be staying on what I’m on.
Thanks for the information you provided. One thing to consider is that many of us look at inhibition of CYP3A4 as a “positive” for rapamycin absorption because it allows one to achieve the same blood levels at lower doses. So “getting off” all of these supplements is not necessary if you reduce the dose. More reason to make sure and test sirolimus blood levels for the dosage you are taking and if too high, reduce the dose.
Thank you. I cannot get off some of these supplements.
I’ll be moving some to 2-3 times per week, removing a few, and keeping others entirely.
With all this complexity, I think I should stay at 4mg rapa instead of increasing to 6mg.
I need to look into the feasibility of getting a blood test. Ty!