Rapamycin induced insulin resistance and drop in testosterone

#141

I use glycine whenever I need to add sugar. It also provides a longevity boost in addition to making your drink sweet! Win-win.

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#142

I agree. Glycine is naturally sweet. I add it to my cacao drinkr, morning coffee. I have used Allulose if and when Ican buy it on discounted price.

2 Likes
#143

I am looking for a microdosing GLP-1 alternative, given that I am not qualified for the prescription.

#144

I generally use sucralose but want to lessen the amount I take in as I use it in my coffee and my protein powder is sweetened with it. I don’t mind the taste and it doesn’t upset my GI. However I have to limit the amount of allulose or taglatose I take in or I predictably get GI upset.

Do the GI effects of these other sweeteners go away with continued consistent use or do others have the same issues?

#145

I would look for a different protein powder.

Per the OpenEvidence.com AI
“Sucralose use is associated with increased risk of adverse metabolic and cardiovascular outcomes, including insulin resistance and coronary heart disease, and its long-term safety remains under active investigation.”

Artificial Sweeteners and Risk of Cardiovascular Diseases: Results From the Prospective NutriNet-Santé Cohort.
Debras C, Chazelas E, Sellem L, et al.
BMJ (Clinical Research Ed.). 2022;378:e071204. doi:10.1136/bmj-2022-071204.

Nonnutritive Sweeteners and Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies.
Azad MB, Abou-Setta AM, Chauhan BF, et al.
CMAJ : Canadian Medical Association Journal = Journal De l’Association Medicale Canadienne. 2017;189(28):E929-E939. doi:10.1503/cmaj.161390.

#146

New podcast: You can have normal glucose and still have insulin resistance.

Sign of insulin resistance: skin tags, especially in the neck area, dry skin, and lower pulse pressure > 40

Dr. Ben Bikman: How To Reverse Insulin Resistance Through Diet, Exercise, & Sleep

#147

Remind us what are your stacks and what is HbA1C?

#148

My HBA1C is a littl high at 5.6 but on a downwards trend.

My stack is found here:

1 Like
#149

Thanks! What do you think of the comments from AI: * Zinc 50 mg daily (or even 3× wk) can push copper low → consider 2 mg copper every other day if you stay on that dose.

  • Mag-citrate 210 mg gives only ~60 mg elemental Mg – low if you’re aiming for 400-500 mg/d; you get more from diet or add a second cap.

  • Lithium orotate 5 mg elemental is micro-dose, but still check 6-monthly eGFR if you keep it long-term.

  • Creatine + empagliflozin: both can nudge creatinine up – monitor eGFR; stay hydrated.

  • NAC 2 g is fine, but stop 48 h before any elective surgery (bleeding risk).

1. LONGEVITY / mTOR–AMPK–AUTOPHAGY
Rapamycin 3 mg w/ GFJ + EVOO – once weekly
Metformin XR 500 mg at night
Empagliflozin 12.5 mg morning

2. LIPIDS / CV
Atorvastatin 5 mg at night
Telmisartan 20-40 mg morning – STOPPED (low BP)

3. HORMONE / PROSTATE / HAIR
Dutasteride 0.5 mg at night
Horbaach Prostate Support (dose per cap)
Zinc 50 mg Mon-Wed-Fri

4. COGNITION / NEURO
Galantamine 4 mg at night
Lithium orotate 5 mg Mon & Thu
NMN 1 g morning
CoQ10 100 mg Mon-Wed-Fri
Coffee 1 & 2 (4 cups total)
Decaf chamomile/berry tea night

5. JOINTS / SKIN / GUT
Collagen peptides 11 g
Hyaluronic acid 500 mg
Glycine 5 g morning + 5 g night
Turmeric + black pepper
Magnesium citrate 210 mg
Brillo EZ 1 tab night

6. PERFORMANCE / BODY-COMP
Creatine monohydrate 5 g
Taurine 6 g
Citrulline 2 g
Whey 25 g (switching to plant)

7. MICRONUTRIENTS / ANTIOXIDANTS
Vitamin D3 5 000–10 000 IU morning
Vitamin B12 2 000 mcg morning
Super B-Complex Mon & Thu
NAC 2 g
Lutein 20 mg + Zeaxanthin 4 mg

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#150

@DeStrider, I asked what protective agent is for kidney protection for the stack:

1. Hydration – cheapest “renoprotective drug”

  • Target: ≥ 2 L water/day (3 L if sauna/cardio / low-carb).

  • Tip: 0.3-0.5 g added sodium (¼ tsp pink salt) on fasting or ketogenic days prevents SGLT-2-induced intravascular volume collapse.

2. Omega-3 (EPA + DHA) – 2-3 g daily

  • Mechanism: lowers intrarenal inflammation, reduces proteinuria, antagonizes RAAS-mediated vasoconstriction.

  • Evidence: meta-analysis of 688 patients showed 16 % reduction in UACR vs. placebo without eGFR harm.

  • Product: triglyceride-form fish oil 2 000-3 000 mg (EPA 60 % / DHA 40 %) with food.

3. Dietary nitrate (beet-root juice or concentrate) – 400 mg nitrate (≈ 250 mL juice) 3-4× wk

  • Mechanism: nitric-oxide donor → vasodilates renal medulla → lowers intraglomerular pressure (same pathway as SGLT-2-i but complementary).

  • Human data: 6-wk crossover in T2D showed ↓ cystatin-C 8 % and ↑ eGFR 4 mL/min vs. placebo (p<0.05).

4. Co-Enzyme Q10 (ubiquinol) – 200 mg with largest fat-containing meal

  • Mechanism: mitochondrial antioxidant; lowers tubular oxidative stress; may blunt rapamycin-induced fibrosis signal.

  • Evidence: small RCT in diabetic CKD showed ↓ serum creatinine 0.15 mg/dL and ↓ MDA (lipid peroxidation) after 12 wk; certainty low but no adverse renal signal.

5. High-molecular-weight Hyaluronic acid – you already take 500 mg; keep it

  • Bonus: animal model shows ↓ tubulointerstitial fibrosis via CD44 inhibition; human safety clear.

6. Potassium-citrate OR bicarbonate-citrate – 1 200 mg (≈ 20 mEq alkali) twice daily with meals only if 24-h urine pH < 5.8 or serum HCO₃ < 24 mmol/L

  • Mechanism: lowers renal acid load → slows eGFR decline 0.5-1 mL/min/yr in meta-analysis of non-dialysis CKD.

  • Caveat: check serum K⁺ first; if >5.0 mmol/L use sodium-bicarbonate instead; re-check K⁺ and BP within 2 wk.

7. Taurine – you already take 6 g; that’s the renoprotective dose

  • Mechanism: osmoregulator + antioxidant; RCT showed 6 g/day ↓ urinary NGAL (tubular injury marker) 18 % in T2D.

8. Lutein + Zeaxanthin – you take 20 mg/4 mg; keep it

  • Extra: small study shows carotenoids ↓ urinary 8-isoprostane (oxidative stress) independent of vitamin E.

9. Vitamin D₃ – you take 5 000-10 000 IU; ensure 25-OH-D 40-60 ng/mL

  • Meta: every 10 ng/mL ↑ 25-OH-D associates with 3 % ↓ albuminuria.

  • Monitor: 25-OH-D & serum Ca every 6 mo; stop if Ca >2.55 mmol/L.

10. Protein ceiling & plant-swap – you’re switching whey → plant; perfect

  • Target: ≤ 1.2 g/kg BW/day total protein; emphasize soy/pea (lower renal acid load, higher arginine → NO generation).

What NOT to add

  • Vitamin C > 500 mg/day – oxalate-stone risk.

  • Vitamin A or E – accumulate in CKD.

  • NSAIDs – obvious.

  • High-dose curcumin (>1 000 mg extract) – may chelate iron & raise oxalate; food-level turmeric you use is fine.

1 Like
#151

Thanks @Jonas that’s a really nice summary! My kidneys are doing great and my EGFR is 108. I’m quite pleased with that.

As soon as I finish my current Zinc tablets, I’m switching to a Zinc and Copper formula. The bottle is sitting on my shelf.

Magnesium Citrate is supplemental. I also take Magnesium Threonate at night (Magtein). I figure I’m covered between the two.

Brillo EZ is for lipids - Bempedoic Acid and Ezetemibe. It’s not for joints.

Excellent posts. I enjoyed reading them. It helps me to realize that I have a pretty good stack. :slight_smile: Thank you.

1 Like
#152

Thanks for sharing your stack!

Moving to a different topic, has anyone tried grounding sheets for sleep? I have started trialing it, so far, I’m very pleased. Calmer, and sleep better.

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