Rapamycin for teeth/periodontal disease

#1

Hi, I’m new here so maybe this has been covered. I have periodontal disease and was considering taking rapamycin for my teeth specifically bone loss.Has any one taking rapamycin noticed changes in their teeth health and what would be the recommended dosage for this. Thanks

1 Like
#2

Use search to find earlier discussion on this.
Adding rapamycin to toothpaste does much.

What evidence do you have of rapamycin affecting bone loss?

#3

I saw the study that showed increased bone growth in mice in regards to their teeth. I was wondering if anyone else had saw some improvement in that regard, bone growth

1 Like
#4

My dental pockets improved.

4 Likes
#5

Thank you for response how much are you taking and for how long

#6

With rapamycin tablets and/or toothpaste?

#7

I’m not currently takin rapamycin but might consider it in any form if it helps with teeth especially peridontal disease. Just looking for other people’s experiences and what they are doing

#8

Yes I know, my question was for @Curious :slight_smile: And welcome here!

1 Like
#9

I use rapamune tablets. I hope this as a general rejuvenating effect.

1 Like
#10

Anecdotally I would say my Gums have had almost no pockets when measured by my dentist since I started Rapamycin. I use to have really bad pockets. But I was already on a trend of improvement. So correlation is not necessarily causation.

5 Likes
#11

I used to have deep pockets as well. The combination of an anti bacterial toothpaste and Rapamycin did the trick. My gums rarely bleed anymore and no more pockets.

3 Likes
#12

Yes - there is some good research on rapamycin potentially helping with this… studies are ongoing. See these threads:

4 Likes
#13

Unfortunately, Rapamycin has not treated my periodontal disease. I have received weekly 6 mg of Rapamycin for 5 years. I gave breaks from 3 to 6 months to time.

2 Likes
#14

Welcome to the site Sadik.

You might want to look into topical use (rapamycin toothpaste): DIY Rapamycin Toothpaste and Flossing Paste

1 Like
#15

I previously posted results from my first cleaning after starting rapamycin. My gaps improved dramatically.

2 Likes
#16

I also saw my dental pockets improve. In 6 months taking rapa every other week, they moved from 4 to a 3 grade.

2 Likes
#17

I found sucking melatonin reduced gum inflammation.

1 Like
#18

I am 69 years old and exercise 6 days a week plus Keto and intermittent fasting. I have been taking a 6 mg dose weekly with 3-4 week breaks every 3 months for 14 months now. I have not noticed many changes but I believe in the promise of the longevity research. The one positive I did notice very quickly was less gum bleeding. I have read many other posts saying something similar.

3 Likes
#19

My gums are noticeably pinker when I’m on it vs. when not.

1 Like
#20

There are some interesting preliminary studies on rapamycin and bone health, but evidence specifically for periodontal disease in humans is still very limited. Maintaining strong oral health through regular professional care remains crucial. Clinics like Burwood Diamond Dental in Burwood, NSW, emphasise preventative strategies, personalised treatment plans, and bone-supporting therapies, which can make a meaningful difference for patients concerned about bone loss.

If considering rapamycin, discussing it with a medical professional is important, as dosing for dental bone effects hasn’t been established. Meanwhile, routine check-ups, professional cleanings, and targeted periodontal treatments can help stabilise gum health and reduce bone loss risk. More research is needed before rapamycin can be confidently recommended for teeth.

For more guidance on clinically proven approaches to support periodontal health, their website:burwooddiamonddental.com.au offers insights on available treatments and preventative care.