Has the group addressed all the hair vitamins on the market and if anything is worth trying?
My friend has been raving about this Mary Ruth supplement, but I wonder if there is a real benefit to this, or any of the competing brands… thoughts?
Unless you have deficiencies, don’t bother.
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There is a separate thread on this forum about it. Some are actually testing it and may report their findings hopefully soon.
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Minoxidil growth peaks after 6 months so about now would be the time some hyperresponder should be seeing huge results on monotherapy if that sugar really works as a growth stimulant.
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See this thread Researchers reveal new molecular mechanism for stimulating hair growth - #5 by RapAdmin
Another new product for stimulating hair growth:
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01 https://www.sciencedirect.com/science/article/abs/pii/S0923181117300269
02 https://www.sciencedirect.com/science/article/abs/pii/S0378512214003259
03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims.
04 https://karger.com/drm/article/239/4/533/836627/Cellular-Senescence-Ageing-and-Androgenetic
05 https://www.jidonline.org/article/S0022-202X(15)33852-5/fulltext
06 https://pubmed.ncbi.nlm.nih.gov/39614601/
07 https://pmc.ncbi.nlm.nih.gov/articles/PMC5556182/
08 Zonari, A., et al. npj Aging, 2023
09 Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR and dermaroller daily. Results based on self-perception reporting and clinical measurements of anagen hairs per cm2, intermediate terminal hairs, hair shaft thickness, inter follicular mean distance, hair count per cm2, and scalp microbiome.
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Could any beta-blocker have the same effect if combined with Rhynchophylline (Cat’s claw)? I wouldn’t want to switch from Nebivolol, but could easily add Cat’s claw to try.
I’ve been thinking about giving this a try in addition to the potent topical I’m using. Although, their OS-1 Face cream didn’t do much for me.
Yes, Its interesting but I need to review the science they point to.
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Happened to come across this:
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It’s available in Liposomal form from vendors already, if someone wants to try it.
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I’m doing a deep dive on reversing gray hair right now and I’m coming across some really interesting stuff, just happened across that.
Only thing to note is it was administered via injection: “We identified the hair grew out in advance in the shaving area of C57BL/6N mice after the treatment of liposomal honokiol (Lip-honokiol) by daily abdominal injection.”
Honokiol has been on my list of things to try. Even if I don’t have any hair loss, it seems like it would be good for many things.
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Protective Effect of Hydroxygenkwanin against Hair Graying Induced by X-Ray Irradiation and Repetitive Plucking
I’ve learned that nicotine, independent from smoking and tobacco, can negatively affect hair and lead to possible hair loss. This means gum, pouches, patches, etc.
Interrupts hair cycle, can cause diffuse hair loss and inhibits 3α-hydroxysteroid dehydrogenase which is an enzyme that breaks down DHT.
Nicotine interrupts hair cycle
“Nicotine is known to cause constriction of dermal hair papilla and local ischemia, accumulation of DNA damage, dysregulation of protease/antiprotease systems involved in the hair growth cycle, and upregulation of local pro-inflammatory cytokines implicated in follicular inflammation and fibrosis [40, 41]. A hypothesis exists that exogenous nicotine from smoking can cause overstimulation of the cellular nicotinic acetylcholine receptors leading to desensitization of the receptor. This in turn contributes to hair follicle destruction by activation of programmed cell death pathways present in keratinocytes” - The Effects of Smoking on Hair Health: A Systematic Review The Effects of Smoking on Hair Health: A Systematic Review - Anna’s Archive
Nicotine can lead to diffuse hair loss
“Nicotine treated mice, 78.6%, but none of control of mice, developed neoplasms originating from the uterus or skeletal muscle. Examination of the uterine neoplasms revealed leiomyosarcomas, composed of whorled bundles of smooth-muscle like cells with large and hyperchromatic nuclei. Sections of the thigh neoplasms revealed densely cellular tumors composed of plump spindle cells, with occasional formation of ‘strap’ cells, containing distorted striations. Both neoplasms were positive for desmin staining. A solitary pulmonary adenoma with papillary architecture also occurred in one nicotine treated mouse. Experimental mice also developed transient balding starting as small patches of alopecia that progressed to distinct circumscribed areas of complete hair loss or large areas of diffuse hair loss.” Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine https://www.sciencedirect.com/science/article/abs/pii/S0024320512001890
Nicotine inhibits an enzyme that breaks down DHT
“We have recently observed that cigarette smoking affects plasma androgen concentrations. The effects of nicotine and cotinine, two products of cigarette smoking, on testosterone metabolism were determined. The activity of delta 4 steroid 5α-reductase, which converts testosterone to 5α-dihydro-testosterone (DHT) was measured in isolated dog prostate nuclei using testosterone (0–200nM) as substrate and NADPH as cofactor. Activity of 3α-hydroxysteroid dehydrogenase (HSD), which converts DHT to 3α-androstanediol (3α-diol) and is a reversible enzyme, was measured in isolated dog prostate microsomes with DHT (0–20M) as substrate and NADPH as cofactor. When microsomal fractions were incubated for 1 hour with and without nicotine (0–50M) and cotinine (0–100M), enzyme activity of HSD was significantly suppressed (p < 0.001). The Vmax was not affected significantly (p > 0.60) and Km increased with increasing concentrations of nicotine and cotinine (p < 0.05). Both nicotine and cotinine are competitive inhibitors of HSD in dog prostate microsomes with Ki’s of 61 and 89M, respectively. The apparent 5α-reductase activity was unaffected by nicotine and cotinine. The inhibitors produced a marked effect on activity of HSD when used in concentrations achieved in humans who smoke cigarettes. The results suggest that nicotine and cotinine are competitive inhibitors of the HSD, an important enzyme involved in the metabolism of DHT and produce an accumulation of DHT. These products of cigarette smoking could alter androgen action in tissue such as skin and prostate.” - Nicotine and cotinine effects on 3 alpha hydroxysteroid dehydrogenase in canine prostate https://www.sciencedirect.com/science/article/abs/pii/S0024320588800018
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A new paper…
Rationale: Hair loss affects millions globally, with limited effective treatments available and significant psychological impacts. Mesenchymal stem cells (MSCs) and MSC-derived exosomes hold therapeutic potential by modulating cellular communication, reducing inflammation, and supporting hair follicular regeneration. Rapamycin, a mechanistic target of rapamycin (mTOR) inhibitor, enhances MSC therapeutic potential by promoting the release of growth factors and signaling molecules. Thus, this study explores the benefit of priming effect of rapamycin on enhancing the function of MSC-derived exosomes to promote hair regrowth in a depilation-induced murine model.
Methods: MSCs were primed with rapamycin, and exosomes were extracted from the MSC-conditioned media using ultrafiltration and poly (ethylene glycol) (PEG) precipitation. Dermal fibroblasts were treated with several doses of exosomes to evaluate the in vitro effect of rapamycin-primed MSC-derived exosomes (REXO). The depilated mice were administered exosomes via intradermal route and the hair regrowth was monitored for 15 days, followed by gene expression analysis and histological examination.
Results: Dermal fibroblasts treated with REXO showed a higher proliferation rate and an increase in genes related to Wnt/β-catenin signaling, autophagy, and growth factors compared to non-primed MSC-derived exosomes (CEXO). In vivo REXO therapy via intradermal injection to the depilated areas in mice enhanced hair follicle development, hair density, and hair activation markers compared with the control and naive exosome treatments.
Conclusion: REXO therapy effectively enhances hair regrowth thus this approach could offer a clinically effective therapy for hair loss treatment.
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@relaxedmeatball See @RapAdmin ’s post above.
If I recall, you’ve shared that in your lab, you have not seen how exosomes can penetrate the skin, so I’m curious about your thoughts on this… and if I’m remembering this accurately. I was not planning on repurchasing my Elevai exosomes face serum due to this fact.
FYI, while it doesn’t have rapa, I’ve recently been using Musely modern serum that contains various goodies, and there are also bonus exosomes… I’ve assumed that part was a waste ?
Also, if we are ingesting rapa, do we need more on our scalp?
Instead of 5ARi to prevent the formation of DHT (and other hormones transformed by 5AR), has there ever been an attempt at upregulating the enzymes responsible for breaking down DHT instead?
“DHT is inactivated in the liver and extrahepatic tissues like the skin into 3α-androstanediol and 3β-androstanediol by the enzymes 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid dehydrogenase, respectively.”
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Will have to try this too. I already trying adding a 5 mg finasteride pill to 5% Minoxidil with minimal results - at least I can’t see any difference. Will try crushing a couple rapamycin pills and see it things improve. Thanks for sharing your experience!
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The gal who has cut my hair for years… on my last cut says the crown is great.
I did start taking minoxidil pills orally over a year ago… take two 2.5 mg pills every night… 5 mg total. Helps maintain lower Blood Pressure too.
Role of Oral Minoxidil in Patterned Hair Loss - PMC