Rapamycin for Hair Growth and Hair Pigmentation

Once you apply the DMSO hair tonic, do you rub it in with your fingers or just leave it?

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I use eye dropper application… then rub iit in… comb thru…old towel fluff dry… comb in place.

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So you apply 3 ml of liquid? 1 ml to front, 1ml to middle and 1 ml to crown? I just finished my first batch today and am interested to see how it works.

Thanks for sharing your formula! Good luck to all!

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Exactly. About 2/3 rds full… eyedropper. Front , middle, and back top…after applying - brush… comb it thru. Towel off excess… old hand towel.

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So don’t rub it in with your fingertips after applying? Just comb it and towel off excess?

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Sorry… rub in with finger tips after applying. I brush to stimulate the scalp. Towel dry and comb in place.

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You wrote: Had some Resveratrol and Egcg on hand so thought I would throw it in. If darkens my grey(s) all the better :slight_smile: will take some before and after photos too.

Did you get the rich tint in your hair?

I really like it… nothing but praise from those that notice anything.

Hair feels healthier.

Are you taking an eye dropper squirt of the topical minoxidil 5% orally too??

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I noticed the tint but haven’t gotten comments from the long haired general (yet). No oral minox though I am ordering some 2.5mg from my indiamart supplier. I have had some edema in the past and will pull the rip cord quickly if I get more.

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Yeah. My grey gone blonde is impressive.
So natural and I look a decade younger.

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Found this today at agelessrx.com
DHT Inhibitors for Hair Loss Treatment & Regrowth

When it comes to fighting hair loss, the two most prolific drugs and those most commonly used in the treatment are Minoxidil and Finasteride. At least, that has been the case for the last several decades–until now. There has been a bit of a revolution in the field of hair regrowth over the past couple of years. Keep reading…

Finasteride, while potent, comes with a host of rather unpleasant side effects when taken orally. In response, researchers have discovered an alternative, called dutasteride. Both medications were originally approved for the treatment of enlarged prostate and urination retention.

Then, in 1997, American drug manufacturer Merck & Co released finasteride into the zeitgeist as the active ingredient in Propecia – the brand’s answer to male pattern baldness. Dutasteride received its own FDA approval for scalp hair loss just four years later in 2001, and “has been found in several studies to induce hair regrowth in men more rapidly and to a greater extent than even the highest approved dosage of finasteride.”

A 2017 comparative review published similar findings, noting that an “increase in total hair count per cm[2] representing new growth was significantly higher in dutasteride group (baseline- 223 hair; at 24 weeks- 246 hair) compared to finasteride group (baseline- 227 hair; at 24 weeks- 231 hair).” The converse was also true. In addition to new, quality growth, the Dutasteride group demonstrated a decrease in thin hair count per cm[2].

Finasteride and Dutasteride are 5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers. DHT is a hormone created in the body as a result of testosterone conversion that effectively shrinks hair follicle receptors in the scalp.

Dutasteride is the more efficient treatment for hair loss and regrowth because it is the more complete compound. While finasteride is selective for type II 5AR, dutasteride inhibits both type I and type II.

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What they failed to mention is that there is a trade off. Dutasteride is a lot more likely to cause side effects, as it completely crushes your DHT. On the hair loss forums, it’s clear dutasteride is superior to finasteride- most don’t take it every day and also cycle off of it.

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What is the consensus regarding topical vs. oral use of dutasteride and finasteride?
The side effects of both medications, when taken orally/systemically, can be bad. Wondering if topical maybe a better risk/reward tradeoff.

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The jury is still out on topicals from everything I’ve read.

The rap on finasteride is overblown and, most doctors think, anecdotal/power of suggestion. That and aggressive lawyers who smell class action. Everyone who has an erection fail who is on finasteride immediately thinks that’s the cause.

The sides from dutasteride are seemingly more real- makes sense, as it’s like 95% DHT shutdown vs 65% (if memory serves). Still, again from hair loss forums, seems most don’t have problems with dutasteride and see better results than with finasteride. Again, /tressless has great information and motivational before/after/in between photos.

Frankly, only a hair transplant is going to give me back the “W” recession area in front. Still, before doing so, I’ve considered giving the all out assault of: dutasteride, loniten combo with weekly microneedling (with the rapa, metformin, ECGC topical) and, for good measure, low level laser light therapy as well.

Truth is, ALL of these are proven to work to varying levels (except for the rapa concoction). How additive are they when all used aggressively together? idk. However, I imagine, except for modest improvement, I’d be spinning my wheels because the area I am targeting is the front- where only hyper responders really get back any significant amount (If you are a hyper responder though, the results are unbelievable).

Now, if I had lost a lot on top, I would definitely take this aggressive approach, as I believe it would make a noticeable difference. Younger men tend to do better, but, as we’ve seen from @Agetron crown area, just loniten filled things in nicely. I don’t recall him even being on finasteride (?).

The whole protocol is pretty cheap and the iRestore type laser products have 6 month return policies- so, why not.

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Anti-androgen drugs like finasteride and dutasteride are a lot more effective orally than topically. This is both in studies and littered anecdotally in online forums.

Funnily though, oral minoxidil has been shown to be more effective than topical application… But also has very severe potential side effects that make any sides from finasteride and dutasteride look like nothing.

Also I agree with what DyingSucks said. I’ve been on finasteride for about 3 years and have had no noticeable side effects at all if you want to add that to the anecdotal pot.

Another topical to look out for is pyrilutamide. iirc it’s only to be used as a topical and binds to the dht on the scalp, so it attacks hair loss from a different angle to finasteride and dutasteride. A Chinese company by the name of Kintor has their formula undergoing phase 3 clinical trials in both China and the US, so something to look out for on the horizon.

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DyingSucks - don’t recall him even being on finasteride (?).

Yes been on finasteride since I was in my early 30’s about 32 years. Never had any issues in all those years… urologist says my prostate gland is amazing… size of a guy in his 20’s.

As to sexual function issues… no effect at all.
All normal.

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Saw this summary on ConsumerLab.com on hair growth drugs:

Linked research pubs:

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Hi Agetron. Super nice posts, your journey is amazing. What is your Finasteride routine for prostate health? Thx

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My Finasteride/Proscar routine is take one 5mg pill every other day. It is built up in my system so can take it less often. Initially did one 5 mg pill a day . Since in my early 30’s… so for at least 30 years.

Great prostate gland size and health according to my urologist… small prostate.

Also, no issues with ED… or any side effects.

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Thank you. Great news for you!

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Wow. I didn’t realize that you were actually taking the Proscar dose (5mg) vs the finasteride (1mg)- you’re taking 1/2 the proscar dose, but, still, that’s a LOT. I don’t know if you have any potential downside at that dose for decades, but your dosing is certainly overkill if you’re only taking it for your hair. Because it doesn’t inhibit both receptors (like dutasteride does), you already max out on DHT inhibition around 65% on a much lower dose.

There’s research to suggest that even 1mg/day isn’t needed after the initial build up period. Many take just 1mg 3x/week.

I get the 5mg and use a pill splitter to cut it in 4ths for ~1.25/dose (I started doing this long ago when there was no generic propecia and 5mg proscar pills sold for much less per pill than 1mg propercia).

Anyways, like you, I’ve been taking this for like 25 years with ~7 of those years being 1.25mg 3x/week. My prostate is small as well.

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