Just curious- have you been back to your ophthalmologist, and if so, how is your eye pressure and optic nerves since being on Rapamycin?
From what I have read, age is the biggest risk factor for glaucoma, even trumping elevated intraocular pressure and sever myopia. It may be a leap of logic, but it would seem that your approach of reducing your biological age in all tissues, including the eyes, would potentially mitigate your risk of developing glaucoma.
best wishes on your journey. Please keep us posted.
On the other hand, I had a retinal detachment in early 2022 while taking weekly rapamycin (6mg). I first had vitreous detachment (which comes with it a risk of RD in the ensuing 6 weeks), so I stopped the rapa for a full 8 weeks. Figuring I was out of the woods, I restarted it and the very next day had retinal detachment requiring emergency surgery. I’ve been scared to restart oral rapamycin ever since, even if it’s all just coincidental, since I’m also at future risk of RD in the other eye.
I am considering trying this.
I was thinking 1 mg rapa with 5 drops transcutol, to completely disolve.
Then, mix into a new bottle of Refresh eye lubricating drops.
Is there any obvious flaw or concern about this method?
I have early cataracts as well as age related presbyopia. I am hoping to slow or halt the cataracts.
Dreamdoc, N-Acetyl-Carnosine eyedrops ( Can C ) were a failure for me several years ago. But, the idea of Rapamycin eye drops has come to mind many times since then. The small number of animal trials have information that sounds sort of okay, but without enough precise information for me. So, your approach (and EnrQay’s) seems logical and at a reasonably low dose. But, if you follow through have you thought about any way of making periodic measurements? The process (of improvement?) may be so slow that it’s almost undetectable, sort of like the development phase of cataracts.
Honestly, since I have enough on hand and the materials used are minimal, I’m considering a “what the hell?” approach.
This would be for personal use/research so following up for measurement and data collection are not needed.
If I get improvement, terrific! If not, then at Best, I would have my follow up eye exam results to determine whether or not there was any improvement, not detectable.
Mostly, I’m wondering whether there’s anything to be concerned about if I simply crushed the pill and dissolve it for eyedrop use as described.
I created a 0.13% concentration using 6 mg rapamycin dissolved in transcutol and then saline. Added 5 pls back to a saline eye drops. I now have 30 ml of a 0.13% rapamycin solution.
My plan is to use it twice a week.
No pain when I used it, and my eyes haven’t fallen out yet… All in the name of research!
I don’t. I will use them for a minimum of several months. It seems that if I am trying to resist degradation due to aging, then ongoing use would be needed.
I can see trying rapamycin for the eyes for a variety of conditions, but cataracts have me puzzled. I do have senile cataracts, but they’re still low level (I’ll be 67 soon), and I have a completely different plan for cataracts once they get to be a problem down the road.
My plan is to simply go for IOL in both eyes. The advantages, such as I see them are three fold. One, with good lenses, you will have a much more clear vision (color etc.) than if you stayed with your old natural lenses, no matter how good care of them you took. Two, they should last you much longer, and not keep deteriorating as a natural lens has a tendency to do. Third, you can simultaneously do some corrections so that you may have no/less need for glasses - something that is less of an option with natural lenses (of course, there is LASIK etc.). Now, there are still risks associated with that, surgery, dry eyes, night vision etc., but my thought was that I still have time - my natural lenses are not terrible, so I can wait until the IOL available are even better, as it seems progress is being made pretty rapidly. So I figure by the time I really need them, say, 10 years from now, the IOLs will be pretty darn good, and that’s when I can spring for them.
So, of all the reasons to put rapamycin drops in your eyes, cataracts, or anything to do with the lens, strike me as least meaningful, as that’s something that you can have replaced in due time.
Of course, I might be missing something, so if someone can set me straight and explain what I got wrong, I’d be very grateful!
