Close to 4 weeks of weekly 4mg Sirolimus doses.
I recognize the side effects…
Not sure how accurate the vo2max is from an apple watch. I have done the physiology lab VO2max and find it hard to believe that the watch could achieve much accuracy. Keep tracking it, and perhaps get a real lab vo2max.
I think for most people it takes a minimum of 6 months to start feeling a difference.
Has you body weight changed? VO2 max is O2 per minute per Kg so if the latter decreases VO2 increases…
That said, I wouldn’t trust an Apple Watch to provide accurate data in this regard.