Are we rethinking the standard 6mg Rapamycin one time a week in favor of 1 mg daily?
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My choice is 6-8 mg weekly. Seems to be working ā¦
Consistent great biological age benefits at this dose.
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Have decided to restart Rapamycin, after reading that powerful study on 1 mg/day for 4 months on humans. I quit Rapa because of side effects mainly lower lymphocytes, but maybe the lower dose, though chronic, will give less or no side effects than the higher peak of my weekly 3 mg dose.
The study showed no significant differences in leukocyte counts between treated and placebo, suggesting that the daily 1 mg was not immunosuppressive. Disappointingly, lymphocytes and NLR were apparently not measured.
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Ok so itās now March and I think Iām starting to notice slight immunosuppressive effects. I very rarely get sick but lately Iām catching all the sniffles ā no major sickness or symptoms but things that wouldnāt touch me at all as they pass around the house are definitely taking their time with me too. At first it looked like just seasonal noise but now itās clear that thereās a pattern. But itās been three months and really I could push it if I wanted to but I donāt see any good reasons to.
So washout time for me. Followed by 6 mg/week for a good stretch TBD.
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I havenāt been sick in a few years. Not since I have been taking Rapamycin
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Hmm. Seems like there must be individual variation in reaction. FWIW, the Mannick study seemed to show that everolimus at a reasonable dose (5mg/1-week) results in enhanced immunity and fewer respiratory infections (at least viral). If the same holds for the extremely similar molecule of rapamycin, then one would expect fewer viral infections in general, but as you show, this is not true for everyone. As I very rarely get respiratory infections (no kids, 
), I havenāt noticed the impact of rapa on this either way. You are doing the right thing in taking a break. Speaking just for myself, Iāve always been very cautious in making connections between a drug and some symptom, and even so, Iāve still managed to get it wrong recently (which I will describe one day in a post as a cautionary taleā¦ where I wrongly ascribed arm and scapula pain to bempedoic acid, when in reality it was just a series of coincidences) - however others are likely more observant than me, so that may not be relevant to anyone else.
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I was taking 1mg/day since early December.
That seemed fine in the Mannick study protocol. LaraPo has more experience with this protocol. Iāll just point out that 1mg/day is a higher cumulative dose than most here use 6mg/1-week, because you end up with 7mg a week, and if you take no breaks, itās possible you accumulate without a trough. Nothing wrong, just a different modality. I wonder if you wouldnāt have been happier with 6mg/1-week. YMMV.
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I will be following SteveĀ“s one mg/day with a break every fourth week.
Anything to report on from your protocol?
Here is a comparison of rapamycin 7mg weekly vs 1mg daily.
It takes around 10 days to reach 3ng/ml at 1mg/day.
Interestingly the 7mg/week (same weekly dose) also reaches the same 3ng/ml average but has half of the time way above or below that limit.
Basically people could do 1mg/day for 10 to whatever they want followed by a washout period to adjust the ratio of time spent around 3ng/ml.
BTW Note this has been done with the model fitted with my own blood concentration measurements so there will be some individual variability.
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No issues, should be getting my annual blood panel done soon.
Everything is pretty normal 
When taking 1mg daily, do you simply take it with your other supplements and drugs at the same time in the morning? I wonder about potential interactions, but also worry that daily use can have a negative impact on muscle gain.
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Yes Iāll switch to weekly after some brief washout. The subjects in the Mannick study were older males too. Their mtor was probably at a higher baseline and needed more aggressive dampening. Iām almost 40, 5 foot 3 in the shade, low growth phenotype, very low baseline inflammation. Might have gone past the sweet spot. Itās also possible my back to back sniffles were a coincidence I attributed to rapa but itās unusual for me and why risk it? I will go back to daily dosing later this year for a few months or as long as Iām doing fine on it. Glucose never budged so I donāt think I was experiencing any meaningful mtorc2 suppression. Just starting suspecting some immunosuppression so time to switch it up.
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