I’ve lost 75lbs since November of last year. I’ve lost over 50lbs several times in my life only to gain it all back and then some. I started rapamycin a couple weeks ago. I spent several months reading about it and considering it. The tipping point was when I saw the study about a single high dose of rapamycin resetting the set point after weight loss. I immediately started looking into how I could get my hands on rapamycin! I am more motivated this time than I’ve ever been. I’ve been maintaining for a couple months which it quite an accomplishment for me. Usually I lose the weight and immediately go back to the same old bad habits. Anyway, I’m increasing my dose 1mg per week for now. I just took 3mg yesterday. I’d love to take the “high dose” and hopefully accomplish my goal of resetting the set point but I’m afraid of side effects if I don’t gradually ramp up to that dose. I know rapamycin dosing just of lifespan/healthspan is a struggle for us to figure out. But, have any of the “experts” talked about what kind of a dose might be required to accomplish this?
Tell me about that. Went on Dukan diet for couple months a while back, lost all I needed to lose (30LBS), and gained it back within a year LOL. Have since reduced sugar and processed carbs and have been able to lose some, albeit a bit slower than I would like. Sex and food my two guilty pleasures, can’t go much long without them 
Hopefully, RAPA will compensate for the abuse.
As for dosing I went 2MG first week, 5mg second week, and 10mg third week, I am too impatient to wait that long. Didn’t have any side effects other than very first time I started it I had a mouth sore.
While most people approach RAPA as if it was as dangerous as the stuff that Putin uses to poison his adversaries there is reports out there that say, there was an instance that someone took 100mg’s of RAPA trying to commit suicide and all he got was more energy and diarrhea
so do as you wish but IMO no need to wait that long to ramp up the dose. I’m sure others will advise you otherwise.
As far as dose for set point, Can’t help, never heard of such a thing. If I were to guess I’d say it has to be at least 5mg’s?
This study was performed on rats. Single Rapamycin Administration Induces Prolonged Downward Shift in Defended Body Weight in Rats - PMC
From the results:
“Manipulation of set point would be an effective weight loss and maintenance strategy, as deviating from the set point normally results in strong activation of physiological compensatory mechanisms. We showed that acute injection of RAP, which presumably induces a transient suppression of mTOR, can have a long-lasting effect on the set point for body weight, suggesting a novel role of mTOR in body weight regulation. Moreover, a single injection has distinct advantage as it can avoid side effects of chronic RAP administration such as glucose intolerance. We propose that RAP and related compounds could be used as tools to investigate how the defended level (apparent set point) of body weight is determined and to complement other weight loss strategies.”
You know, I’m not too sure how well this “set point” research is going to translate to humans. I’ve taken Rapamycin for almost 4 years now (dosing typically around 6mg/week to 12mg/week, but also up to 28mg at some points) , though I took a significant break for over 6 months this past year while I was participating in a plasmapheresis clinical trial.
During the period of dosing with rapamycin pretty consistently (about 3 years+ ) I lost weight (was also taking metformin for a portion of that time, and metformin helped me lose about 15lbs quickly, and also took SGLT2 inhibitors, which also helped me lose about 10lbs quickly and easily). My weight went down from low to mid 180s to about 160 lbs and held steady there for most of the two years.
But during that pause of rapamycin for 6 months (I also stopped exercising as I got busy with some other work activities) I eventually gained that weight back. I’m now back exercising and losing that weight.
Anyway, all of this is a longwinded way of suggesting that the “set point” may or may not work for you, and the doses that are needed for it may be relatively high and sustained for a while.
Just wanted to share my experience. I’m not super confident that the “set point” reset will work in humans… or it may take a higher dose. your mileage may vary.
Well, at this point I plan on continuing rapa indefinitely regardless. So, I’ll just cross my fingers and hope it resets the set point. I’m not sure what my dosing plan for healthspan is going to be at this point. I’m thinking 6mg/wk or 10mg/10days or 12mg/biweekly. But at some point hopefully I’ll find a maintenance dose that I tolerate well and at that point I’ll probably take a double dose with some GFJ and hope that it resets my set point. If it works it works. If it does’t, I’ll probably just stick with a maintenance dose and hopefully that will help me maintain my weight. I realize the biggest part of winning this battle will come from my own motivation and self discipline.
FWIW, I lost some weight a year or two ago and during last year’s holidays, I had a pretty crappy diet and managed to not gain a significant amount back, which was surprising to me given my own yo-yo history. I take 6mg with no GFJ weekly.
I do think it helps but I also think you can’t completely outrun physics and your base metabolic needs less calories in your new skinnier body.
One way to counteract it is to work on gaining muscle-- I’m pleasantly surprised these days how much more food I can eat by doing resistance training and gaining a little bit more muscle mass coupled with more protein in my diet (1g per ideal body weight which for me is 160g). I’m more satiated with protein, coupled with healthy carbs and fats, I feel like I eat a lot, and my glucose just gets better and better.