Rapamycin can lower body temperature - Anyone Measure This?

Hm, I did not understand this was the case. Can you provide more color/support for this take?

The article you linked seems to think we have healthier metabolic rates given lower levels of inflammation:

the decline in body temperature over time could be that we’re also using less energy and have a lower metabolic rate than in the past.

The reduction may be due to a population-wide decline in inflammation. Generally, inflammation increases our metabolism and raises temperature.

Because of improvements in public health, this could be why inflammation has decreased. The ambient temperatures we live in, thanks to heating and air conditioning, could be factors in lower metabolic rates.

“I think it’s most likely because we have much less inflammation in our bodies now than we did when the standard was developed in the mid-19th century,” Parsonnet said.

“We have less inflammation because we have far fewer chronic infectious diseases like tuberculosis and periodontal disease, far less recurrent infection, shifts in our microbiomes, and we also have learned how to combat inflammation directly through better diets, and also with things like nonsteroidal drugs and statins,” she explained.

Thoughts on body temperature:

Looking at the remaining data, they found that temperatures were variable based on age, sex, height, weight, and time of day. Women tended to have higher temperatures than men, while temperatures tended to decrease with age, and slightly increased with weight and height. The biggest influence on body temperature was the time of day, with temperatures lowest in the early morning and highest around 4pm.

“Most people, including many doctors, still think that everyone’s normal temperature is 98.6°F [37°C],” senior study author and professor of medicine Dr Julie Parsonnet said. “In fact what’s normal depends on the person and the situation, and it’s rarely as high as 98.6°F [37°C].”

Overall, the average “normal” temperature was found to range from 36.3°C (97.3°F) to 36.8°C (98.2°F), with an overall average of 36.6 C (97.9 F). Given how much it varies with individual characteristics, however, the team has put together an online tool to see where your own temperature lies in the range.

and:

another interesting device for monitoring core temperature:

and another newly approved device:

Aion Biosystems announced today that it received FDA 510(k) clearance for its iTempShield device and software system.

iTempShield received approval for use in adults and children five years of age and older. It covers use in hospitals, outpatient facilities, remote patient monitoring environments and over-the-counter sales.

Boston-based Aion designed the quarter-sized, skin-wearable monitoring device with support from cloud-based software and proprietary algorithms. It enables the continuous measurement of body temperature for a variety of clinical applications. That includes oncology sepsis monitoring, post-surgical infection detection, long-term monitoring and consumer home health.

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Another recent study on this theme…

Continuous wrist temperature monitoring can uncover insights into the potential for future disease risk for ailments like Type 2 diabetes, hypertension, liver disease, kidney failure, and more. These new findings from Perelman School of Medicine researchers, published in Nature Communications, shows that accurate, continued digital monitoring of skin temperature can give deeper medical insights.

Previously, disrupted temperature rhythms had only been linked to a handful of conditions, such as metabolic syndrome and diabetes. Now, this research provides insights from a large population, and it indicates a wider spectrum of conditions are associated with poor temperature rhythms, measured in wrist temperature amplitude (the difference between the minimum and maximum temperature over the course of 24 hours).

Journal Article (open access)

Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank

https://www.nature.com/articles/s41467-023-40977-5

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Don’t know if this is of interest but this company in the UK are developing a drug that lowers temperature as a way to slow aging.

They currently have a wefunder page.

Apologies if this has been posted already.

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Yeah and almost certainly not. We have way more inflammation these days due to metabolic disease and NAFLD and visceral fat. We have way more tissue iron and much less mitochondrial efficiency. These all cause reduced body temperature. In addition, to lower body temperature there are significant circadian rhythm disturbances.

The key point is to assess metabolic function both via chemistry, organ and functional performance. Overlay temperature with sleep metrics and HRV and then work to optimize these and you will see body temperature improve.

Then start to perform hormetic challenges and track the changes to make sure you are heading in the direction you want to go.

Further improvement in metabolic health.
Improvements or changes in functional markers that have declined with age.
Maintenance of skeletal muscle and further reduction in visceral fat.
Improvement in Glycan and Omic protein patterns

We are all different and while we all need oxygen, water and carbon to ignite for energy production once we get past these life required the amount will vary considerably.

Find what works for you but don’t just guess. It is not easy but the rewards of staying functional, youthful and vital for when reprogramming is a reality will be worth it. For me it is.

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For those of you using an Oura ring, is it accurate? And how much variability is there? Obviously it’s not measuring core temperature.

It detected every time I got fever after covid vaccines.

Are you able to see a temperature level? I seem to only see some “delta in temp vs my base line”.

Withins - may be only “deltas from baseline” and not the actual levels as they say “baseline day and night temperature fluctuations” and “to deliver a best-in-class body temperature variation assessment”…

Core - interesting and reasonable cost, will email and ask them some questions

Aion - may perhaps be the best one, but don’t see how to buy as a normal retail customer?

No it only shows the deviation, fever can be +1.4-2 C the next day, etc.

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