Rapamycin as adjunctive to measles vaccine

I had a liver transplant 7 years ago (fatty liver cirrhosis). Two years ago I got the Docs to change my immunosuppression to Rapa. It’s one mg/day but sometimes I lose some for a while, and find them later, behind the GFJ, y’know.

I want to be a volunteer “transplant mentor”, but I don’t have the required antibody titers for mumps (from infection or vaccine). I got measles and rubella as a kid (born in '56). But now they won’t let me have the (MMR) vaccine because they’re live viruses.

I want the MMR vaccine because I beat the shit out of dying and pulled off a metabolic overhaul “like you read about”, and I want to help others. Not to mention, I keep finding my wife and me for weeks at a time, in Central Mexico or the ruins of Copan (oh my god!), deep in Honduras, eating in a farmer’s kitchen who’s never seen a vaccine. Yeah, and maybe for my ego too.

I see my transplant docs in person soon. The Immunology docs whom my PCP contacted said “They should test my CD4/CD8 ratio,” so I’ll be talking about that.

OK, anyone, please educate me. I know on a “Wikipedia” level that generally CD4+ T-cells are like Golden Doodles, while CD8+ are like pitbulls, and a ratio of 2:1 or better CD4/CD8 is indicative of good immune function (at least adaptive immunity), and low systemic inflammation. Are there other clinical tests to predict vaccine success?

And other than the 2013? Joan Mannick, Lloyd Klickstein Novertis clinical trials of Rapamycin proceeding flue vaccine, is there other good research or maybe other clinical trials where Rapa has proved to be an adjunctive (a boosting agent) for vaccination response?
Cheers

1 Like

If you had measles as a child, why do you want the vaccine? Have you tested for antibodies?